The Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Model

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dc.contributor.authorAkman, Tulay
dc.contributor.authorAkman, Levent
dc.contributor.authorErbas, Oytun
dc.contributor.authorTerek, Mustafa Cosan
dc.contributor.authorTaskiran, Dilek
dc.contributor.authorOzsaran, Aydin
dc.date.accessioned2019-10-27T22:30:52Z
dc.date.available2019-10-27T22:30:52Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractPeripheral neurotoxicity is a frequent dose-limiting side effect of the chemotherapeutic agent cisplatin. This study was conducted to investigate the preventive effect of oxytocin (OT) on cisplatin-induced neurotoxicity in rats. Forty-four adult female rats were included in the study. Thirty-six rats were administered intraperitoneally (i.p.) single dose cisplatin 10mg/kg and divided in to 3 groups. The first group (n = 12) received saline i.p whereas the second group (n = 12) and the third group (n = 12) were injected with 80 mu g/kg and 160 mu g/kg OT, respectively, for 10 days. The remaining 8 rats served as the control group. Electromyography (EMG) studies were recorded and blood samples were collected for the measurement of plasma lipid peroxidation (malondialdehyde; MDA), tumor necrosis factor (TNF)-alpha and glutathione (GSH) levels. EMG findings revealed that compound muscle action potential amplitude was significantly decreased and distal latency was prolonged in the nontreated cisplatin-injected rats compared with the control group (P < 0.005). Also, nontreated cisplatin-injected rats showed significantly higher TNF-alpha and MDA levels and lower GSH level than control group. The administration of OT significantly ameliorated the EMG alterations, suppressed oxidative stress and inflammatory parameters, and increased antioxidative capacity. We suggest that oxytocin may have beneficial effects against cisplatin-induced neurotoxicity.en_US
dc.identifier.doi10.1155/2015/167235en_US
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid25688351en_US
dc.identifier.urihttps://doi.org/10.1155/2015/167235
dc.identifier.urihttps://hdl.handle.net/11454/51287
dc.identifier.wosWOS:000349078100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.relation.ispartofBiomed Research Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Preventive Effect of Oxytocin to Cisplatin-Induced Neurotoxicity: An Experimental Rat Modelen_US
dc.typeArticleen_US

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