Lipoprotein-associated phospholipase A(2): a new marker to determine cardiovascular risk in hypercholesterolemic dyslipidaemic children

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dc.contributor.authorOngen, Belkiz
dc.contributor.authorUcar, Sema Kalkan
dc.contributor.authorLevent, Erturk
dc.contributor.authorAzarsiz, Elif
dc.contributor.authorKologlu, Turan
dc.contributor.authorCoker, Mahmut
dc.contributor.authorSozmen, Eser
dc.contributor.authorSagin, Ferhan G.
dc.date.accessioned2019-10-27T11:06:20Z
dc.date.available2019-10-27T11:06:20Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Inflammation and hypercholesterolaemia contribute to atherosclerotic changes which can start in childhood. Children with hyperlipidaemias are at high risk for early coronary atherosclerosis. This study evaluates the relationship between lipoprotein-associated phospholipase A(2) (Lp-PLA(2)), carotid intima-media thickness (CIMT) and flow-mediated dilatation in hypercholesterolaemic dyslipidaemic children. Methods We performed a case-control study consisting of 43 cases, aged 2 to 17 years, and 24 age-matched controls. Fasting blood samples were obtained from both groups for the measurement of a lipid profile (total cholesterol, LDL-C, HDL-C and triglycerides) and Lp-PLA(2) in mass units. The latter was determined with a turbidimetric immunoassay method (PlacTest, DiaDexus Inc.) applied to an automated analyser. CIMT and flow-mediated dilatation measurements were undertaken by a paediatric cardiologist, using high-resolution B-mode ultrasonography. Results Total cholesterol, LDL-C and Lp-PLA(2) concentrations were significantly higher in the cases than in the controls (p<0.001 for all three parameters). While CIMT values were also significantly higher in the patients compared to the controls (P=0.001), flow-mediated dilatation values were significantly lower (P=0.001). We found positive correlations between Lp-PLA(2) and total cholesterol (r=0.41, P=0.001), Lp-PLA(2) and LDL-C (r=0.36, P=0.004), Lp-PLA(2) and CIMT (r=0.44, P=0.019) and LDL-C and CIMT (r=0.41, P=0.032); there were negative correlations between Lp-PLA(2) and flow-mediated dilatation (r=-0.15, P=0.045), total cholesterol and flow-mediated dilatation (r=-0.45, P=0.017), LDL-C and flow-mediated dilatation (r=-0.51, P=0.006) and CIMT and flow-mediated dilatation (r=-0.45, P=0.016). Conclusion Lp-PLA(2) concentrations are significantly elevated in hypercholesterolaemic dyslipidaemic children. Given the association of Lp-PLA(2) with markers of atherosclerosis (total cholesterol, LDL-C, CIMT and flow-mediated dilatation), the finding of increased concentrations of Lp-PLA(2) could be used to identify early atherosclerotic changes in hypercholesterolaemic dyslipidaemic children and may inform their clinical management.en_US
dc.description.sponsorshipEge University Research FundEge University [2010-TIP-075]en_US
dc.description.sponsorshipThis research was funded by Ege University Research Fund (2010-TIP-075).en_US
dc.identifier.doi10.1177/0004563216671338en_US
dc.identifier.endpage547en_US
dc.identifier.issn0004-5632
dc.identifier.issn1758-1001
dc.identifier.issue5en_US
dc.identifier.pmid27614353en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://doi.org/10.1177/0004563216671338
dc.identifier.urihttps://hdl.handle.net/11454/31836
dc.identifier.volume54en_US
dc.identifier.wosWOS:000407512700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAnnals of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypercholesterolaemiaen_US
dc.subjecthyperlipidaemiaen_US
dc.subjectchildrenen_US
dc.subjectatherosclerosisen_US
dc.subjectlipoprotein-associated phospholipase A(2)en_US
dc.subjectcarotid intima-media thicknessen_US
dc.subjectflow-mediated dilatationen_US
dc.titleLipoprotein-associated phospholipase A(2): a new marker to determine cardiovascular risk in hypercholesterolemic dyslipidaemic childrenen_US
dc.typeArticleen_US

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