Acromegaly is associated with high fibroblast growth factor-21 levels

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dc.contributor.authorYurekli, B. S.
dc.contributor.authorKutbay, N. O.
dc.contributor.authorAksit, M.
dc.contributor.authorSuner, A.
dc.contributor.authorSimsir, I. Y.
dc.contributor.authorSeckiner, S.
dc.contributor.authorKocabas, G. U.
dc.contributor.authorBozkaya, G.
dc.contributor.authorSaygili, F.
dc.date.accessioned2019-10-27T09:59:23Z
dc.date.available2019-10-27T09:59:23Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractPurposeFibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition.MethodsWe studied 43 subjects (21 females and 22 males, mean age of 50.012.8) with acromegaly. The control group consisted of 40 gender- and age-matched subjects (25 females and 15 males, mean age of 48.88.8). Acromegaly patients were classified into two groups; active acromegaly (AA; n=26) and controlled acromegaly (CA; n=17). Metabolic, anthropometric and laboratory values of subjects were recorded. FGF-21 level was measured by ELISA assay.Results Median FGF-21 levels were significantly higher in acromegaly group compared to control group (85.5 vs. 59.0pg/mL, p=0.02, respectively). In the multiple regression model, FPG, A1c, HOMA-IR, glucose intolerance, BMI, visceral fat, hs-CRP, presence of hypertension, dyslipidemia and acromegaly were included as independent variables to explain variability of plasma FGF-21 levels in whole study group. The presence of acromegaly was the only determinant of increased FGF-21 levels in the whole study group ( coefficient=0.253, p=0.006).Conclusion FGF-21 levels were increased significantly in acromegaly group. Increased FGF-21 levels were significantly and independently associated with the state of acromegaly. Acromegaly may also be a FGF-21 resistance state independent from insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemia.en_US
dc.identifier.doi10.1007/s40618-018-0885-1en_US
dc.identifier.endpage60en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue1en_US
dc.identifier.pmid29754168en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage53en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-018-0885-1
dc.identifier.urihttps://hdl.handle.net/11454/29612
dc.identifier.volume42en_US
dc.identifier.wosWOS:000454270400007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGHen_US
dc.subjectFGF-21en_US
dc.subjectAcromegalyen_US
dc.titleAcromegaly is associated with high fibroblast growth factor-21 levelsen_US
dc.typeArticleen_US

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