Evaluation of the effects of miRNAs in familial Mediterranean fever

Basit Öğe Kaydı
dc.contributor.authorHortu, Hacer Orsdemir
dc.contributor.authorKaraca, Emin
dc.contributor.authorSozeri, Betul
dc.contributor.authorGulez, Nesrin
dc.contributor.authorMakay, Balahan
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorAtik, Tahir
dc.contributor.authorTekin, Ismihan Merve
dc.contributor.authorUnsal, Sevket Erbil
dc.contributor.authorCogulu, Ozgur
dc.date.accessioned2019-10-27T09:45:59Z
dc.date.available2019-10-27T09:45:59Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.description.abstractFamilial Mediterranean fever (FMF) is an inherited autoinflammatory disorder that can result in attacks with accompanying recurrent episodes of fever, serositis, and skin rash. MiRNAs are demonstrated to be associated with a number of other diseases; however, no comprehensive study has revealed its association with FMF disease. The aim is to investigate the role of microRNAs in FMF. We included 51 patients with genetically diagnosed FMF who had clinical symptoms and 49 healthy volunteers. Fifteen miRNAs that were found to be associated with autoinflammatory diseases and have a part in immune response were evaluated. The expression levels of 11 miRNAs (miR-125a, miR-132, miR-146a, miR-155, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, and miR-34a) in the patient group were significantly low, compared with the control group (p<0.05). The patient group was analyzed and compared within itself, and the expression levels of 5 miRNAs (miR-132, miR-15a, miR-181a, miR-23b, miR-26a) in the patients who took colchicine seemed to have increased and levels of 5 miRNAs (miR-146a, miR-15a, miR-16, miR-26a, miR-34a) in the patients who took colchicine were significantly lower (p<0.05). Furthermore, the attack patients were compared with the control group, and their expression levels of 4 miRNAs (miR-132, miR-15a, miR-21, miR-34a) were significantly lower (p<0.05). Levels of 9 miRNAs (miR-132, miR-146a, miR-15a, miR-16, miR-181a, miR-21, miR-223, miR-26a, miR-34a) in non-attack patients decreased significantly (p<0.05). Our study demonstrates that miRNAs could be effective in the pathogenesis of FMF.en_US
dc.identifier.doi10.1007/s10067-017-3914-0en_US
dc.identifier.endpage643en_US
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue3en_US
dc.identifier.pmid29442258en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage635en_US
dc.identifier.urihttps://doi.org/10.1007/s10067-017-3914-0
dc.identifier.urihttps://hdl.handle.net/11454/29213
dc.identifier.volume38en_US
dc.identifier.wosWOS:000460116500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer London Ltden_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamilial Mediterranean feveren_US
dc.subjectMEFVen_US
dc.subjectMicroRNAen_US
dc.titleEvaluation of the effects of miRNAs in familial Mediterranean feveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu