The Relationship of Serum Diabetes Antibodies With the Development of Early Diabetic Retinopathy Findings in Children With Type 1 Diabetes Mellitus

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dc.authorid0000-0001-8081-0465
dc.authorid0000-0002-8268-536X
dc.authorid0000-0001-6359-1600
dc.contributor.authorKorkmaz, Hueseyin Anil
dc.contributor.authorDogan, Beyza
dc.contributor.authorDevebacak, Ali
dc.contributor.authorDegirmenci, Cumali
dc.contributor.authorAfrashi, Filiz
dc.date.accessioned2025-04-25T07:56:37Z
dc.date.available2025-04-25T07:56:37Z
dc.date.issued2024
dc.departmentEge Üniversitesi, Tıp Fakültesi, Cerrahi Bilimler Bölümü, Göz Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose:To explore how serum diabetes autoantibodies are related to the development of early diabetic retinopathy in children with type 1 diabetes mellitus. Methods: In this prospective and observational study, 62 patients with type 1 diabetes mellitus who had not yet developed clinical diabetic retinopathy were followed up for at least 5 years. Healthy volunteers aged 10 to 20 years were also included. Insulin, pancreatic islet cells, and glutamic acid decarboxylase (GAD) autoantibodies were measured with an RIA kit at the time of type 1 diabetes mellitus diagnosis. Optical coherence tomography angiography (OCTA) was used to evaluate the foveal avascular zone (FAZ) and parafoveal vascular density (PVD) for the development of early diabetic retinopathy among the groups. Patients'OCTA findings were compared with those of healthy volunteers. The obtained data were analyzed via IBM SPSS Statistics for Windows, version 27.0. Spearman's rank correlation test and regression analysis were performed to determine independent predictors of OCTA and type 1 diabetes mellitus parameters. Results: Eighteen boys and 44 girls with type 1 diabetes mellitus with a median age of 15.6 years (range: 10.08 to 20.88 years) were evaluated. Healthy control participants with a median age of 15.3 years (range: 14.2 to 18.2 years) were also included. The mean FAZ was greater in the type 1 diabetes mellitus group than in the healthy control group (P = .013 and .119, respectively). The mean PVD was significantly lower in the type 1 diabetes mellitus group than in the healthy control group. There was no significant correlation between serum diabetes autoantibodies (GAD and insulin autoantibodies) and FAZ or PVD (FAZ and GAD; r = 0.138, P = .286, FAZ and anti-insulin; r = 0.100, P = .441, PVD and GAD; r =-0.151, P = .24, PVD and anti-insulin; r =-0.087, P = .499). Conclusions: Type 1 diabetes mellitus in children without clinically detectable diabetic retinopathy is associated with impaired retinal microcirculation and irregularities at the FAZ margin. Impaired retinal microcirculation and irregularities were associated with glycated hemoglobin levels in the study group. Thus, studies with larger patient series are needed.
dc.identifier.citationKorkmaz, H. A., Dogan, B., Devebacak, A., Degirmenci, C., & Afrashi, F. (2025). The relationship of serum diabetes antibodies with the development of early diabetic retinopathy findings in children with type 1 diabetes mellitus. Journal of Pediatric Ophthalmology and Strabismus, 62(2), 135-142.
dc.identifier.doi10.3928/01913913-20241121-03
dc.identifier.issn01913913
dc.identifier.issueDec
dc.identifier.pmid39749985
dc.identifier.scopus2-s2.0-105001528800
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3928/01913913-20241121-03
dc.identifier.urihttps://hdl.handle.net/11454/117156
dc.identifier.wosWOS:001419282100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDevebacak, Ali
dc.institutionauthorDegirmenci, Cumali
dc.institutionauthorAfrashi, Filiz
dc.institutionauthorid0000-0001-8081-0465
dc.institutionauthorid0000-0002-8268-536X
dc.institutionauthorid0000-0001-6359-1600
dc.language.isoen
dc.publisherSLACK Inc.
dc.relation.ispartofJournal of Pediatric Ophthalmology & Strabismus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleThe Relationship of Serum Diabetes Antibodies With the Development of Early Diabetic Retinopathy Findings in Children With Type 1 Diabetes Mellitus
dc.typeArticle

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