The protective effect of resveratrol against dentin bonding agents-induced cytotoxicity

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dc.contributor.authorAtalayin, Cigdem
dc.contributor.authorArmagan, Guliz
dc.contributor.authorKonyalioglu, Sibel
dc.contributor.authorKemaloglu, Hande
dc.contributor.authorTezel, Huseyin
dc.contributor.authorErgucu, Zeynep
dc.contributor.authorKeser, Aysegul
dc.contributor.authorDagci, Taner
dc.contributor.authorOnal, Banu
dc.date.accessioned2019-10-27T22:58:57Z
dc.date.available2019-10-27T22:58:57Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractThis study was designed to evaluate the cytotoxicity of four dentin bonding agents and the effects of an antioxidant addition. Group A: G-aerial Bond, Group B: Optibond All in One, Group C: Gluma Self Etch and Group D: Clearfil S-3 Bond were added to the medium using extract method. The cells were cultured with or without resveratrol (RES) addition. MTT, reactive oxygen species (ROS), DCF, Comet and 8-OHdG measurements were performed. The agents had a dose-dependent (1:1>1:10>1:20) cytotoxic effect. Considering 1:10 concentration; Group D at 1 h (p<0.01) and Group B and D at 24 h had the weakest cytotoxic effect (p<0.05). After RES addition, the highest cell viability was determined in Groups B+RES and D+RES at 1 h and in Groups A+RES and B+RES at 24 h (p<0.01). The dentin bonding agents induced ROS production and DNA damage regarding to their composition. However, RES addition decreased the indicated parameters.en_US
dc.description.sponsorshipEge University's Scientific Research FoundationEge University [2012-Dis-022]en_US
dc.description.sponsorshipThis study was supported by Ege University's Scientific Research Foundation (2012-Dis-022). The authors would also like to thank Prof. S. Ismet Deliloglu Gurhan and Mehmet Ozgun Ozen for their kind help in providing cells.en_US
dc.identifier.doi10.4012/dmj.2015-079en_US
dc.identifier.endpage773en_US
dc.identifier.issn0287-4547
dc.identifier.issue6en_US
dc.identifier.pmid26510940en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage766en_US
dc.identifier.urihttps://doi.org/10.4012/dmj.2015-079
dc.identifier.urihttps://hdl.handle.net/11454/51685
dc.identifier.volume34en_US
dc.identifier.wosWOS:000368755700005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Soc Dental Materials Devicesen_US
dc.relation.ispartofDental Materials Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectCytotoxicityen_US
dc.subjectDentin bonding agenten_US
dc.subjectResveratrolen_US
dc.titleThe protective effect of resveratrol against dentin bonding agents-induced cytotoxicityen_US
dc.typeArticleen_US

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