Immunohistochemical expressions of p16 and p53 proteins in cervical intraepithelial neoplasia and in benign cervical tissue

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dc.contributor.authorTosun G.
dc.contributor.authorSendag F.
dc.contributor.authorZeybek B.
dc.contributor.authorCosan Terek M.
dc.contributor.authorGuven C.
dc.contributor.authorZekiogly O.
dc.contributor.authorBilgin O.
dc.date.accessioned2019-10-26T22:19:33Z
dc.date.available2019-10-26T22:19:33Z
dc.date.issued2010
dc.departmentEge Üniversitesien_US
dc.description.abstractPurpose of Investigation: To evaluate the immunohistochemical expressions of p16 and p53 in cervical intraepithelial neoplasia (CIN) and do a comparison with non-neoplastic cervical lesions. Methods: Sixty cases diagnosed as CIN after histopathological examination and 25 controls diagnosed as chronic cervicitis were included in the study. Immunohistochemical expressions for pi6 and p53 were evaluated and compared in all cases. The cases in the study were defined according to the Bethesda system. Of these, 31.8% (n = 27) had a low-grade squamous intraepithelial lesion (LGSIL), and 38.8% (n = 33) had a high-grade squamous intraepithelial lesion (HGSIL). Results: There was a statistically significant difference between chronic cervicitis and CIN in terms of p53 and pl6 expression levels (p = 0.001). On the other hand, the level of p16 expression was statistically different between LGSIL and HGSIL (p = 0.001), while there was no significant difference in terms of p53 expression. Among the HGSIL cases (n = 33), 91% had pl6 expression, while 66.7% (n = 27) of the LGSIL patients had no p16 expression. In the chronic cervicitis group, 84% (n = 21) did not reveal any p16 expression, while 96% (n = 24) did not reveal any p53 expression. Various levels of p53 expressions were detected in 59.2% (n = 16) of CIN1 cases, 69.3% (n = 9) of CIN2 cases, and 90% (n = 18) of CIN3 cases. Conclusion: While pl6 is useful in detecting high-grade cervical lesions, p53 is not a good biomarker for distinguishing high-grade lesions from low grade ones.en_US
dc.identifier.endpage631en_US
dc.identifier.issn0392-2936
dc.identifier.issue6en_US
dc.identifier.pmid21319504en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage627en_US
dc.identifier.urihttps://hdl.handle.net/11454/19554
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic cervicitisen_US
dc.subjectCINen_US
dc.subjectP16en_US
dc.subjectP53en_US
dc.titleImmunohistochemical expressions of p16 and p53 proteins in cervical intraepithelial neoplasia and in benign cervical tissueen_US
dc.typeArticleen_US

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