Chitotriosidase enzyme activity: is this a possible chronic inflammation marker in children with common variable immunodeficiency and early atherosclerosis?

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dc.contributor.authorAzarsiz, Elif
dc.contributor.authorKaraca, Neslihan
dc.contributor.authorLevent, Erturk
dc.contributor.authorKutukculer, Necil
dc.contributor.authorSozmen, Eser
dc.date.accessioned2019-10-27T10:48:23Z
dc.date.available2019-10-27T10:48:23Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground Common variable immunodeficiency is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in common variable immunodeficiency patients has not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in paediatric common variable immunodeficiency patients. Methods Common variable immunodeficiency patients (n=24) and healthy controls (n=23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%). Results In patients, the mean chitotriosidase activity (8.986.28) was significantly higher than the controls (5.17 +/- 3.42) (P=0.014). Chitotriosidase showed positive relation with hs-CRP (P=0.011) and SAA (P=0.011) but had no relation with ferritin (P=0.155), HDL (P=0.152) or LDL-cholesterol (P=0.380). Mean cIMT increased in patients compared with the controls (P<0.001) but did not show any relation with chitotriosidase (P=0.546). FMD% decreased in patients (P<0.001) also showing no relation with chitotriosidase (P=0.298). Ventricular myocardial performance indexes had no significant difference, but RVEF% decreased in patients (P=0.043). Conclusions High chitotriosidase activity in common variable immunodeficiency patients demonstrated in vivo the presence of activated macrophages indicating ongoing inflammation. Echocardiographic diastolic functional deficiency, increased cIMT and decreased FMD% may be accepted as early atherosclerotic findings, but none of them showed relationship with chitotriosidase activities.en_US
dc.identifier.doi10.1177/0004563216675647en_US
dc.identifier.endpage643en_US
dc.identifier.issn0004-5632
dc.identifier.issn1758-1001
dc.identifier.issue6en_US
dc.identifier.pmid27705887en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage636en_US
dc.identifier.urihttps://doi.org/10.1177/0004563216675647
dc.identifier.urihttps://hdl.handle.net/11454/31534
dc.identifier.volume54en_US
dc.identifier.wosWOS:000413505500003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAnnals of Clinical Biochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrimary immunodeficiencyen_US
dc.subjectchitotriosidaseen_US
dc.subjectatherosclerosisen_US
dc.subjectinflammationen_US
dc.titleChitotriosidase enzyme activity: is this a possible chronic inflammation marker in children with common variable immunodeficiency and early atherosclerosis?en_US
dc.typeArticleen_US

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