Facilitated Subcutaneous Immunoglobulin Treatment Increases the Quality of Life and Decreases the Number of Infections and Hospitalizations in Children with Primary Immunodeficiencies

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dc.authoridTOPYILDIZ, Ezgi/0000-0002-9260-8157;
dc.contributor.authorErbas Acici, Nida
dc.contributor.authorTopyildiz, Ezgi
dc.contributor.authorAyguen, Ayse
dc.contributor.authorGeyik, Mehmet
dc.contributor.authorEdeer Karaca, Neslihan
dc.contributor.authorAksu, Guzide
dc.contributor.authorKutukculer, Necil
dc.date.accessioned2024-08-31T07:48:21Z
dc.date.available2024-08-31T07:48:21Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Immunoglobulin replacement therapy is an effective lifelong treatment modality used in patients with primary immunodeficiency to prevent and/or reduce the incidence of serious infections. Facilitated subcutaneous immunoglobulin (fSCIG) was developed to combine the advantages of intravenous immunoglobulin (IVIG) and subcutaneous immunoglobulin (SCIG) and is the latest method of immunoglobulin G (IgG) administration. In this study, switching to fSCIG administration in primary immunodeficiency patients receiving regular IVIG or SCIG therapy was evaluated, and serum IgG trough levels, frequency of infections, frequency and duration of hospitalizations, duration of absence from school/work, and quality of life were determined. Methods: In this study, fifteen patients with primary immunodeficiency who were previously receiving IVIG or SCIG treatment, followed by fSCIG, were evaluated retrospectively. Age, diagnosis, current complications, mean IgG value, frequency of infection, frequency of hospitalization, and duration of absenteeism from school and work were recorded during and before fSCIG treatment. At the beginning of fSCIG treatment, at 6th and 12th months, The Quality of Life Scale was also evaluated in patients and parents. Results: The most common indications for initiation of fSCIG treatment were the difficulty of access to the hospital and the long transfusion periods. No systemic adverse reactions were reported except for redness, swelling, and mild pain on the injection site. The median IgG values for the last 1 year were 529.6 mg/dL for IVIG (n = 9), 876.2 mg/dL for SCIG (n = 6) and 856.7 mg/dL for fSCIG (n = 15, all patients) treatment. The frequency of infections and the number of hospitalizations decreased significantly in the fSCIG group compared to both previous treatment modalities. There was a significant increase in the quality of life score of the patients and their families when compared with previous treatment modalities. Conclusion: fSCIG is an effective treatment method and is well tolerated in patients with immunodeficiency. It provides stable immunoglobulin levels and excellent protection against infections and offers the patients the possibility of home-based therapy.en_US
dc.identifier.doi10.1159/000534900
dc.identifier.endpage391en_US
dc.identifier.issn1018-2438
dc.identifier.issn1423-0097
dc.identifier.issue4en_US
dc.identifier.pmid38246144en_US
dc.identifier.scopus2-s2.0-85183833834en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage382en_US
dc.identifier.urihttps://doi.org/10.1159/000534900
dc.identifier.urihttps://hdl.handle.net/11454/104746
dc.identifier.volume185en_US
dc.identifier.wosWOS:001148433500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectFacilitated Subcutaneous Immunoglobulinen_US
dc.subjectImmunoglobulin Replacement Therapyen_US
dc.subjectPrimary Immunodeficiencyen_US
dc.subjectQuality Of Lifeen_US
dc.subjectChildrenen_US
dc.titleFacilitated Subcutaneous Immunoglobulin Treatment Increases the Quality of Life and Decreases the Number of Infections and Hospitalizations in Children with Primary Immunodeficienciesen_US
dc.typeArticleen_US

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