Comparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Model

Basit Öğe Kaydı
dc.authorscopusid57211521019
dc.authorscopusid6602535110
dc.authorscopusid35201180000
dc.authorscopusid57202063760
dc.authorscopusid55469991100
dc.authorscopusid55318033800
dc.authorscopusid56376463500
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.contributor.authorKaya, Huseyin
dc.contributor.authorSabah, Dundar
dc.contributor.authorKececi, Burcin
dc.contributor.authorKucuk, Levent
dc.contributor.authorErbas, Oytun
dc.contributor.authorOltulu, Fatih
dc.contributor.authorYigitturk, Gurkan
dc.date.accessioned2023-01-12T19:59:26Z
dc.date.available2023-01-12T19:59:26Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstractAim of the study: Biologic reconstruction using tumor-bearing bone autografts devitalized by liquid nitrogen or extracorporeal irradiation (oncological sterilization) is a safe and effective method in musculoskeletal surgery. The purpose of this study was to examine the effects of these two oncological sterilization methods on nerve recovery. Methods: A total of 48 rats were randomly divided into 3 groups as autograft, irradiation and liquid nitrogen groups. A nerve defect created in the right sciatic nerve was reconstructed with an autograft obtained from the nerve itself. Group I underwent reconstruction with standard nerve autograft. Group II and Group III underwent reconstruction with devitalized nerve autograft treated through extracorporeal irradiation and liquid nitrogen, respectively. The left sciatic nerves of the rats served as control. Electromyography, motor function test and histomorphological analysis were performed to assess the nerve recovery on the 3rd (early stage) and 4th months (late stage). Results: Electrophysiological assessment revealed better results in irradiation group compared with liquid nitrogen group in terms of myelinization and axonal regeneration. Motor performance of the autograft group was slightly better than the other groups. Histologically, autograft group demonstrated better results compared with other groups. Late-stage assessments revealed high rates of myelinization in the graft segment in liquid nitrogen group and in the segment distal to the graft in irradiation group. Conclusions: This study has demonstrated that nerve autografts treated by oncological sterilization methods may be used for nerve reconstruction in limb salvage surgery. However, further studies are needed to clarify the applicability of these methods.en_US
dc.description.sponsorshipEge University Scientific Research Foundation [15-TIP-013]en_US
dc.description.sponsorshipThis work was supported by Ege University Scientific Research Foundation (15-TIP-013).en_US
dc.identifier.doi10.1080/08941939.2019.1691686
dc.identifier.endpage783en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue7en_US
dc.identifier.pmid32013622en_US
dc.identifier.scopus2-s2.0-85078915383en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage773en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2019.1691686
dc.identifier.urihttps://hdl.handle.net/11454/77171
dc.identifier.volume34en_US
dc.identifier.wosWOS:000512563000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNerve recoveryen_US
dc.subjectlimb salvageen_US
dc.subjectextracorporeal irradiationen_US
dc.subjectliquid nitrogenen_US
dc.subjectnerve autograften_US
dc.subjectbone tumoren_US
dc.subjectMusculoskeletal Tumor Surgeryen_US
dc.subjectClinical-Experienceen_US
dc.subjectMotor Functionen_US
dc.subjectBone Segmentsen_US
dc.subjectGraftsen_US
dc.subjectAllograften_US
dc.subjectReimplantationen_US
dc.subjectRevascularizationen_US
dc.subjectReconstructionen_US
dc.subjectRegenerationen_US
dc.titleComparison of the Effects of Extracorporeal Irradiation and Liquid Nitrogen on Nerve Recovery in a Rat Modelen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu