FACTORS AFFECTING DRUG INTERACTIONS AND THEIR CLINICAL IMPORTANCE IN GERIATRIC OUTPATIENTS

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dc.authoridErtuna, Elif/0000-0001-9061-146X
dc.authoridArun, Mehmet Zuhuri/0000-0002-9704-9737
dc.authorscopusid56332865400
dc.authorscopusid58405264600
dc.authorscopusid6603335681
dc.authorscopusid36572380900
dc.authorscopusid15080556500
dc.authorwosidErtuna, Elif/HJY-5009-2023
dc.contributor.authorArun, Mehmet Zuhuri
dc.contributor.authorYildiz, Iffet Zeynep
dc.contributor.authorTaskiran, Emin
dc.contributor.authorSahin, Sevnaz
dc.contributor.authorErtuna, Elif
dc.date.accessioned2024-08-25T18:45:23Z
dc.date.available2024-08-25T18:45:23Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractIntroduction: Polypharmacy can lead to drug-drug interactions. The aim of this study was to determine the possible factors affecting the prevalence and clinical importance, and interrater reliability of clinical significance of drug interactions in geriatric outpatients. Materials and Method: Potential drug-drug interactions in 228 patients treated in an outpatient geriatric clinic were evaluated in this cross-sectional, retrospective study. The potential significance of the interactions was reviewed separately by a geriatrician and a clinical pharmacist.Results: A total of 1342 drugs were prescribed (median 6 [2-14], per patient). Mean age of the patients was 78 & PLUSMN;0.5 (65-96). Polypharmacy was present in 64.0% of the patients. A weak positive correlation was found between patient age and the number of drugs used (Rs =.205; p=.002). No drug interaction was detected in 18.0% of the patients. In the prescriptions of the remaining 187 patients 760 category C, 70 category D, and 18 category X interactions (Lexicomp & REG;) were detected. A strong positive correlation was found between the number of drugs per patient and the number of drug interactions (Rs =.734; p<.001). There was a strong correlation between the number of interactions and the presence of polypharmacy (rpb=.702, p<.001). The measure of agreement between the clinicians was more pronounced for category D and X interactions (Cohen's K=.714 and 1, p<.001).Conclusion: Advanced age, a higher frequency of concomitant use of drugs, and polypharmacy are factors that require clinicians to be aware of drug-drug interactions. Clinical pharmacists can work with geriatricians in outpatient clinics to prevent drug interactions.en_US
dc.identifier.doi10.29400/tjgeri.2023.336
dc.identifier.endpage117en_US
dc.identifier.issn1304-2947
dc.identifier.issn1307-9948
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85163696207en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage107en_US
dc.identifier.trdizinid1188609en_US
dc.identifier.urihttps://doi.org/10.29400/tjgeri.2023.336
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188609
dc.identifier.urihttps://hdl.handle.net/11454/101528
dc.identifier.volume26en_US
dc.identifier.wosWOS:001022169400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGunes Kitabevi Ltd Stien_US
dc.relation.ispartofTurkish Journal of Geriatrics-Turk Geriatri Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240825_Gen_US
dc.subjectDrug Interactionsen_US
dc.subjectPolypharmacyen_US
dc.subjectHealth Services for the Ageden_US
dc.subjectPharmacisten_US
dc.subjectElderly Outpatientsen_US
dc.subjectPolypharmacyen_US
dc.subjectConsequencesen_US
dc.subjectPredictorsen_US
dc.titleFACTORS AFFECTING DRUG INTERACTIONS AND THEIR CLINICAL IMPORTANCE IN GERIATRIC OUTPATIENTSen_US
dc.typeArticleen_US

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