In vitro evaluation of apoptosis with Tc-99m-glucoheptonate

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dc.contributor.authorKocagozoglu, Gamze
dc.contributor.authorLambrecht, Fatma Yurt
dc.contributor.authorGunduz, Cumhur
dc.contributor.authorYucebas, Musteyde
dc.contributor.authorTabar, Elif Bayrak
dc.contributor.authorOzgur, Aykut
dc.contributor.authorBalci, Tugce
dc.date.accessioned2019-10-27T21:24:02Z
dc.date.available2019-10-27T21:24:02Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractRadiopharmaceuticals are useful to evaluate effectiveness of cancer treatments as well as diagnosis of diseases. Tc-99m-Glucoheptonate has high sensitivity for imaging lung cancer tissues. In this study, the potential use of Tc-99m-glucoheptonate for monitoring apoptosis related to chemotherapeutic agents is investigated in vitro using A549 lung cancer cell line. A decrease in Tc-99m-glucoheptonate uptake ratio was observed depending on the level of apoptosis. Tc-99m-glucoheptonate is found to be useful for the detection of apoptosis following treatment in A549 lung tumor cells. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDepartment of Scientific Projects at Ege University, Izmir, TurkeyEge Universityen_US
dc.description.sponsorshipThe authors gratefully acknowledge the financial support received from Department of Scientific Projects at Ege University, Izmir, Turkey.en_US
dc.identifier.doi10.1016/j.apradiso.2011.03.006en_US
dc.identifier.endpage959en_US
dc.identifier.issn0969-8043
dc.identifier.issue7en_US
dc.identifier.pmid21459007en_US
dc.identifier.startpage955en_US
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2011.03.006
dc.identifier.urihttps://hdl.handle.net/11454/44315
dc.identifier.volume69en_US
dc.identifier.wosWOS:000291456300007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofApplied Radiation and Isotopesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectCanceren_US
dc.subjectTc-99men_US
dc.subjectTc-99m-glucoheptonateen_US
dc.titleIn vitro evaluation of apoptosis with Tc-99m-glucoheptonateen_US
dc.typeArticleen_US

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