Human stretch reflex pathways reexamined

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dc.contributor.authorYavuz, S. Utku
dc.contributor.authorMrachacz-Kersting, Natalie
dc.contributor.authorSebik, Oguz
dc.contributor.authorUnver, M. Berna
dc.contributor.authorFarina, Dario
dc.contributor.authorTurker, Kemal S.
dc.date.accessioned2019-10-27T22:05:22Z
dc.date.available2019-10-27T22:05:22Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractReflex responses of tibialis anterior motor units to stretch stimuli were investigated in human subjects. Three types of stretch stimuli were applied (tap-like, ramp-and-hold, and half-sine stretch). Stimulus-induced responses in single motor units were analyzed using the classical technique, which involved building average surface electromyogram (SEMG) and peristimulus time histograms (PSTH) from the discharge times of motor units and peristimulus frequencygrams (PSF) from the instantaneous discharge rates of single motor units. With the use of SEMG and PSTH, the tap-like stretch stimulus induced five separate reflex responses, on average. With the same single motor unit data, the PSF technique indicated that the tap stimulus induced only three reflex responses. Similar to the finding using the tap-like stretch stimuli, ramp-and-hold stimuli induced several peaks and troughs in the SEMG and PSTH. The PSF analyses displayed genuine increases in discharge rates underlying the peaks but not underlying the troughs. Half-sine stretch stimuli induced a long-lasting excitation followed by a long-lasting silent period in SEMG and PSTH. The increase in the discharge rate, however, lasted for the entire duration of the stimulus and continued during the silent period. The results are discussed in the light of the fact that the discharge rate of a motoneuron has a strong positive linear association with the effective synaptic current it receives and hence represents changes in the membrane potential more directly and accurately than the other indirect measures. This study suggests that the neuronal pathway of the human stretch reflex does not include inhibitory pathways.en_US
dc.description.sponsorshipMarie Curie Chair Project (GenderReflex)European Union (EU) [MEX-CT-2006-040317]; Turkish Scientific and Technological Research Organization GrantTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK-107S029-SBAG-3556]; European Research Council Advanced GrantEuropean Research Council (ERC) [DEMOVE 267888]; Det Obelske Familiefond; Danish Government Scholarship Cultural Agreements [2010/11]en_US
dc.description.sponsorshipThis study is supported by Marie Curie Chair Project (GenderReflex) MEX-CT-2006-040317, Turkish Scientific and Technological Research Organization Grant TUBITAK-107S029-SBAG-3556, European Research Council Advanced Grant DEMOVE 267888, and the Det Obelske Familiefond. S. U. Yavuz, O. Sebik, and M. B. Unver are supported by Danish Government Scholarship Cultural Agreements 2010/11. K. S. Turker is a Fellow of the Turkish Academy of Sciences Association.en_US
dc.identifier.doi10.1152/jn.00295.2013en_US
dc.identifier.endpage612en_US
dc.identifier.issn0022-3077
dc.identifier.issn1522-1598
dc.identifier.issue3en_US
dc.identifier.pmid24225537en_US
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.1152/jn.00295.2013
dc.identifier.urihttps://hdl.handle.net/11454/48381
dc.identifier.volume111en_US
dc.identifier.wosWOS:000331215500015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofJournal of Neurophysiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthumanen_US
dc.subjectEMGen_US
dc.subjectmuscle spindle reflexen_US
dc.subjectperistimulus time histogramen_US
dc.subjectperistimulus frequencygramen_US
dc.titleHuman stretch reflex pathways reexamineden_US
dc.typeArticleen_US

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