Is obesity a possible modifier of periodontal disease as a chronic inflammatory process? A case-control study

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dc.contributor.authorBuduneli, N.
dc.contributor.authorBiyikoglu, B.
dc.contributor.authorIlgenli, T.
dc.contributor.authorBuduneli, E.
dc.contributor.authorNalbantsoy, A.
dc.contributor.authorSarac, F.
dc.contributor.authorKinane, D. F.
dc.date.accessioned2019-10-27T22:13:49Z
dc.date.available2019-10-27T22:13:49Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground and Objective: This cross-sectional case-control study was conducted to provide a comparative evaluation of clinical periodontal measurements, together with serum levels of certain bioactive peptides and inflammatory cytokines, in relation to obesity. For this purpose, clinical periodontal measurements and the levels of serum leptin, adiponectin, interleukin-6 (IL-6), C-reactive protein and soluble intercellular adhesion molecule-1 of obese female individuals and their nonobese counterparts were compared. Material and Methods: Sixty obese (body mass index (BMI) > 30) and 31 nonobese (BMI < 30) female subjects were recruited for the present study. Before any periodontal intervention, serum samples were obtained and full-mouth clinical periodontal measurements were recorded at six sites per tooth. ELISA was used for the biochemical analysis. Data were tested statistically. Results: Clinical attachment level was significantly higher in the obese group compared with the nonobese control group (p < 0.05). Serum levels of leptin and IL-6 were significantly higher in the obese group (p < 0.05). BMI correlated with the serum levels of inflammatory molecules (p < 0.05), but not with clinical periodontal parameters, in the obese group. Conclusion: In conclusion, obesity does not seem to have a prominent effect on clinical periodontal parameters but it does have many correlations with circulating inflammatory molecules. As suggested in the literature, increased levels of leptin and IL-6 in the obese group might be one explanation for a possible relationship between obesity and periodontal disease. A prospective study is warranted to clarify, in greater detail, the effects of obesity on periodontal health.en_US
dc.description.sponsorshipEge University Research Foundation, Izmir, TurkeyEge University [2009 DIS 021]; University of Louisville, KY, USAen_US
dc.description.sponsorshipThis study was supported by a grant from the Ege University Research Foundation (2009 DIS 021), Izmir, Turkey, and the University of Louisville, KY, USA. The authors declare that they have no conflicts of interest.en_US
dc.identifier.doi10.1111/jre.12125en_US
dc.identifier.endpage471en_US
dc.identifier.issn0022-3484
dc.identifier.issn1600-0765
dc.identifier.issue4en_US
dc.identifier.pmid23919737en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage465en_US
dc.identifier.urihttps://doi.org/10.1111/jre.12125
dc.identifier.urihttps://hdl.handle.net/11454/49881
dc.identifier.volume49en_US
dc.identifier.wosWOS:000339503800006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectadipokinesen_US
dc.subjectcytokinesen_US
dc.subjectenzyme-linked immunosorbent assayen_US
dc.subjectobesityen_US
dc.subjectperiodontal diseaseen_US
dc.subjectserumen_US
dc.titleIs obesity a possible modifier of periodontal disease as a chronic inflammatory process? A case-control studyen_US
dc.typeArticleen_US

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