Autoantibody Positivity in Children with Chronic Diarrhea

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dc.contributor.authorTuhan, Hale
dc.contributor.authorAslan, Aslı
dc.contributor.authorEcevit, Çiğdem Ömür
dc.contributor.authorAzarsız, Elif
dc.contributor.authorKaraca, Neslihan Edeer
dc.contributor.authorÇetin, Funda
dc.contributor.authorAksu, Güzide
dc.date.accessioned2021-05-03T21:13:54Z
dc.date.available2021-05-03T21:13:54Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractAim: We aimed to determine the frequency of autoantibody antinuclear (ANA), peripheral anti-neutrophil cytoplasmic antibody (p-ANCA), antisaccharomyces cerevisiae antibody (ASCA), anti-pancreatic exocrine gland antibody (PAb), goblet cell antibody (GAb) positivities in children with the complaint of chronic diarrhea and inflammatory bowel disease (IBD). We also purposed to explore the role of these autoantibodies in the differential diagnosis of IBD. Materials and Methods: In our study, serum samples of 51 patients with the complaint of chronic diarrhea and 35 healthy controls were analyzed. Clinical and laboratory data at the time of serum sampling were collected and a differential diagnosis was made as the results of performed tests were recorded. For all patients, ANA, p-ANCA, ASCA, GAb, PAb positivities were evaluated by indirect immunofluorescence. The chronic diarrhea group was divided into two groups, namely, the IBD group and non-IBD group. Results: In the chronic diarrhea group, 11 (21.6%) patients had ANA, 3 (5.9%) had p-ANCA, 1 (2%) had PAb, 1 (2%) had Gab and 1 (2%) had ASCA positivity. From the 35 cases of the control group, 8 (22.9%) had ANA, 7 (20%) had ASCA positivity. In the control group, ASCA was found to be high (p=0.007). Six cases were diagnosed as IBD; 1 (16.7%) had ANA, 1 (16.7%) had p-ANCA, 1 (2%) had Gab and 1 (2%) had ASCA positivity. ASCA and GAb positivities were significantly more frequent in the IBD group (p=0.006, p=0.006, respectively). Conclusion: ASCA was determined to be significantly higher in the control group. High positivity in the control group showed that the percentage of nonspecific positivity may be high for this test. ASCA and GAb of those patients with a diagnosis of IBD were found significantly higher. The serologic tests which depend on p-ANCA, ASCA, PAb, GAb can be supportive of diagnoses and differential diagnoses of IBD. Autoantibodies in IBD may be used as a supportive diagnostic tool in selected cases, rather than as the diagnosis of IBD as routine practice.en_US
dc.identifier.doi10.4274/jpr.galenos.2020.13008
dc.identifier.endpage178en_US
dc.identifier.issn2147-9445
dc.identifier.issn2587-2478
dc.identifier.issue3en_US
dc.identifier.startpage172en_US
dc.identifier.trdizinid388290en_US
dc.identifier.urihttps://doi.org/10.4274/jpr.galenos.2020.13008
dc.identifier.urihttps://hdl.handle.net/11454/71686
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/388290
dc.identifier.volume7en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofThe Journal of Pediatric Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleAutoantibody Positivity in Children with Chronic Diarrheaen_US
dc.typeArticleen_US

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