Can urinary biomarkers predict acute kidney injury in newborns with critical congenital

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dc.contributor.authorUygur, Ozgun
dc.contributor.authorKoroglu, Ozge Altun
dc.contributor.authorLevent, Erturk
dc.contributor.authorSozmen, Eser
dc.contributor.authorErgin, Firat
dc.contributor.authorAtay, Yuksel
dc.contributor.authorKultursay, Nilgun
dc.date.accessioned2021-05-03T20:33:21Z
dc.date.available2021-05-03T20:33:21Z
dc.date.issued2021
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground/aim: Congenital heart disease (CHD) is the most common congenital malformation group and is the leading cause of newborn mortality in developed countries. Most of the infants with CHD develop preoperative or postoperative acute kidney injury (AKI). Acute kidney injury may develop before the serum creatinine rise and oliguria. Urinary biomarkers such as kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin (IL)-18, and cystatin C may predict AKI in patients with critical CHD (CCHD) before the serum creatinine rise. in this study, we aimed to determine the AKI incidence among newborn patients with CCHD and investigate the predictivity of urinary biomarkers for AKI. Materials and methods: Newborns with a gestational age >34 weeks and birth weight >1500 g with a diagnosis of CCHD were enrolled in the study. Blood and urine samples were collected at birth, during the first 24-48 h, and in the preoperative and postoperative periods. Results: A total of 53 CCHD patients requiring surgery during the neonatal period were enrolled in the study. The 24-48 h KIM-1 levels of the cases with exitus were higher (P = 0.007). The 24-48 h cystatin C and preoperative NGAL levels were higher in patients with postoperative AKI (P = 0.02). Conclusion: in newborns with CCHD, high KIM-1 levels may predict mortality, whereas high cystatin C and preoperative NGAL levels may be indicative of AKI. These biomarkers deserve further investigation in larger study populations.en_US
dc.description.sponsorship[BAP-2014-TIP-038]en_US
dc.description.sponsorshipAcknowledgements/disclaimers/conflict of interest The authors have no potential conflicts of interest to disclose. This study was funded by a local scientific study project group (BAP-2014-TIP-038) . The authors have no financial relationships relevant to this article to disclose.en_US
dc.identifier.doi10.3906/sag-2004-370en_US
dc.identifier.endpage180en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid33021763en_US
dc.identifier.scopus2-s2.0-85102311963en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage175en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2004-370
dc.identifier.urihttps://hdl.handle.net/11454/69991
dc.identifier.volume51en_US
dc.identifier.wosWOS:000623196400022en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute kidney injuryen_US
dc.subjectcardiovascular surgeryen_US
dc.subjectcritical congenital heart diseaseen_US
dc.subjectnewbornen_US
dc.subjecturinary biomarkeren_US
dc.titleCan urinary biomarkers predict acute kidney injury in newborns with critical congenitalen_US
dc.typeArticleen_US

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