Antiviral and cytotoxic activities and chemical profiles of two species of Abies nordmanniana from Türkiye

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dc.authoridÇÖVEN, Furkan Ozan/0000-0001-7696-3418
dc.contributor.authorSarikahya, Nazli
dc.contributor.authorOkkali, Gaye Sumer
dc.contributor.authorCoven, Furkan Ozan
dc.contributor.authorZeinal, Sevda
dc.contributor.authorGucur, Gulce
dc.contributor.authorCaglar, A. Dila
dc.contributor.authorUyar, Ece
dc.date.accessioned2024-08-31T07:46:43Z
dc.date.available2024-08-31T07:46:43Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractAbies is an important genus of the family Pinaceae, with about 50 species found in the highlands of Asia, Europe, North Africa, and North and Central America. The principal aim of the present work was to investigate the chemical content and biological potential of the resin and cone from Abies nordmanniana subsp. bornmulleriana and Abies nordmanniana subsp. equi-trojani , respectively. The flavonoid and phenolic contents of the resin and cones were evaluated using liquid chromatography -high resolution mass spectrometry (LC-HRMS). Additionally, the essential oil and fatty acid compositions were analyzed using gas chromatography -mass spectrometry (GC -MS) and gas chromatography -flame ionization detector (GC-FID), respectively. Cytotoxicity of the extracts and essential oils were screened against certain cancer cell lines, namely, human prostate adenocarcinoma cell line (PC3), human lung adenocarcinoma cell line (A549), human pancreatic cancer cell line (PANC-1), human hepatocellular carcinoma cell line (HepG2), human breast cancer cell line (MDA-MB231), and normal human lung fibroblast cell line (CCD-34-LU), with MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl2H-tetrazolium bromide] assay. According to the MTT results, hexane extracts of both cone (CH) and resin (RH), ethanol -water (CEW), dichloromethane (CD), and acetone (CA) extracts of the cone mostly inflict cytotoxicity in HepG2 cell line. Antiviral activities of Abies nordmanniana subsp. extracts at doses of 5 mu g/g and 10 mu g/g were also evaluated in ovo for their virucidal activity against avian coronavirus. Abies nordmanniana subsp. extracts exhibited concentration -dependent antiviral activity on specific pathogen -free embryonated chicken eggs. Significantly, cone acetone extract (CA), cone ethanol extract (CE), and cone dichloromethane extract (CD) of Abies nordmanniana subsp. exhibited strong inhibition of the virus at a concentration of 10 mu g/g. The most potent virucidal activity was observed with ethanol -water extract of conifer form (CEW). According to these results, it was proved that Abies nordmanniana species could be a potential, sustainable, and renewable drug source, especially considering the impressive antiviral and significant cytotoxic activity potentials.en_US
dc.identifier.doi10.55730/1300-0527.3670
dc.identifier.issn1300-0527
dc.identifier.issue3en_US
dc.identifier.pmid39050931en_US
dc.identifier.scopus2-s2.0-85199379360en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3670
dc.identifier.urihttps://hdl.handle.net/11454/104186
dc.identifier.volume48en_US
dc.identifier.wosWOS:001257612500002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240831_Uen_US
dc.subjectAbiesen_US
dc.subjectResinen_US
dc.subjectConeen_US
dc.subjectCytotoxicityen_US
dc.subjectAntiviral Activityen_US
dc.subjectAvian Coronavirusen_US
dc.titleAntiviral and cytotoxic activities and chemical profiles of two species of Abies nordmanniana from Türkiyeen_US
dc.typeArticleen_US

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