Diabetes mellituslu olgularda 2,3 DPG düzeyleri
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Tarih
1999
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Dergi ISSN
Cilt Başlığı
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
AMAÇ: Diabetes mellituslu olgularda, oksijen bağlama affinitesi oldukça yüksek olan glikolize hemoglobin (HbA1c) artışı, doku hipoksisine neden olur. Bu nedenle de damarsal komplikasyonların gelişiminden sorumlu tutulan faktörlerden birisi olarak kabul edilir. Eritrositlerdeki bu metabolik değişikliği kompanse etmede 2.3 difosfogliseratın (2.3 DPG) rolü tartışılmaktadır. Bu çalışmada tip 1 diabetes mellituslu çocuklarda 2,3 DPG düzeylerinin araştırılması hedeflenmiştir. YÖNTEM: İnsüline bağımlı diabetes mellituslu 31 hastanın 2,3 DPG değerleri, sağlıklı 16 çocuk ile karşılaştırılmıştır. BULGULAR: Diabetli çocuklarda 2,3 DPG değerleri anlamlı olarak yüksek bulunmuştur (p < 0.01) (hasta grubunda 4.85±1.21. kontrol grubunda 3.87±0.54 µmol/ml eritrosit). Diabetli çocuklarda hemoglobin - hematokrit değerleri. HbA1c düzeyleri, serum lipid değerleri ile 2,3 DPG arasında ise korelasyon bulunmamıştır. SONUÇ: Hastaların uzun süreli izlemlerinde gelişebilecek komplikasyonlara ön bilgi vermesi açısından 2,3 DPG 'nin önemi vurgulanmıştır.
OBJECTIVE: Increasing of the glycosylated haemoglobin (HbA1c) which has high oxygen binding capacity cause to tissue hypoxia in diabetes mellitus. Because of this reason it is accepted as a responsible factor for vascular complications. the role of 2,3 diphosphoglycerate (2,3 DPG) for compensating metabolic disturbances in erythrocytes is not revealed clearly yet. in this study, investigation of 2,3 DPG levels in children with diabetes mellitus have been aimed. METHOD: in this study 2,3 diphosphoglycerate levels has been compared with 31 children who are suffered from insulin dependent diabetes mellitus and 16 age matched healthy children. RESULTS: It has been found that diabetic patients have had significantly high 2,3 diphosphoglycerate levels (in diabetic patients 4.85-1.21 µmol/ml erythrocyte, in control group 3.87± 0.54 µmol/ml erythrocyte, (p<0.01). But there was no any correlation between 2,3 diphosphoglycerate and haemoglobin, hematocrit. HbA1c and serum lipid levels. CONCLUSION: Importance of 2,3-diphosphoglycerate evaluation in diabetic children has been emphasised that it should be accepted as a clue for vascular complications which can be occurred in a long follow-up period.
OBJECTIVE: Increasing of the glycosylated haemoglobin (HbA1c) which has high oxygen binding capacity cause to tissue hypoxia in diabetes mellitus. Because of this reason it is accepted as a responsible factor for vascular complications. the role of 2,3 diphosphoglycerate (2,3 DPG) for compensating metabolic disturbances in erythrocytes is not revealed clearly yet. in this study, investigation of 2,3 DPG levels in children with diabetes mellitus have been aimed. METHOD: in this study 2,3 diphosphoglycerate levels has been compared with 31 children who are suffered from insulin dependent diabetes mellitus and 16 age matched healthy children. RESULTS: It has been found that diabetic patients have had significantly high 2,3 diphosphoglycerate levels (in diabetic patients 4.85-1.21 µmol/ml erythrocyte, in control group 3.87± 0.54 µmol/ml erythrocyte, (p<0.01). But there was no any correlation between 2,3 diphosphoglycerate and haemoglobin, hematocrit. HbA1c and serum lipid levels. CONCLUSION: Importance of 2,3-diphosphoglycerate evaluation in diabetic children has been emphasised that it should be accepted as a clue for vascular complications which can be occurred in a long follow-up period.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp
Kaynak
Medical Network Klinik Bilimler ve Doktor
WoS Q Değeri
Scopus Q Değeri
Cilt
5
Sayı
5
