Green Synthesis and Characterization of Magnetic Antibiotic Delivery System Using Linden Extract

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dc.contributor.authorAk, Güliz
dc.date.accessioned2023-01-12T20:29:16Z
dc.date.available2023-01-12T20:29:16Z
dc.date.issued2020
dc.departmentN/A/Departmenten_US
dc.description.abstractGreen chemistry enables iron oxide nanoparticle production with easy, cost-effective and environmentally friendly way. Amoxicillin is used in the treatment of various bacterial infections, however antibiotic resistance is a major problem for treatment. Iron oxide nanoparticles are promising alternatives for overcoming these problems and magnetically targeted antibiotic delivery. In this work, it was aimed to synthesis of iron oxide nanoparticles with green chemistry method utilizing the linden plant, and loading of amoxicillin to these magnetic nanoparticles to be targeted antibiotic delivery system. Iron oxide nanoparticles were prepared using aqueous linden extract and FeCl3 solution. These nanostructures were characterized with FTIR, SEM, and zetasizer. Amoxicillin solutions at varying concentrations were incubated with magnetic nanoparticles for drug adsorption and in vitro drug release from nanoparticles at pH 7.4 was studied. It was found that nanoparticles had spherical morphology (70-88 nm), iron oxide structure and were capped with polyphenols. Optimum amoxicillin amount in magnetic nanoparticles was determined as 100.17 ?g drug/ mg nanoparticle. Drug release was faster in the first hours and proceeded in controlled manner. It can be suggested that amoxicillin loaded iron oxide nanoparticles could have potential of magnetically targeted therapy of bacterial infectious disease with low cost and ecofriendly production.en_US
dc.identifier.doi10.18185/erzifbed.713542
dc.identifier.endpage755en_US
dc.identifier.issn2149-4584
dc.identifier.issue2en_US
dc.identifier.startpage746en_US
dc.identifier.trdizinid477756en_US
dc.identifier.urihttps://doi.org/10.18185/erzifbed.713542
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/477756
dc.identifier.urihttps://hdl.handle.net/11454/80412
dc.identifier.volume13en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleGreen Synthesis and Characterization of Magnetic Antibiotic Delivery System Using Linden Extracten_US
dc.typeArticleen_US

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