Assessment of mTOR pathway molecules during implantation in rats

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dc.contributor.authorEkizceli, G.
dc.contributor.authorInan, S.
dc.contributor.authorOktem, G.
dc.contributor.authorOnur, E.
dc.contributor.authorOzbilgin, K.
dc.date.accessioned2019-10-27T11:19:43Z
dc.date.available2019-10-27T11:19:43Z
dc.date.issued2017
dc.departmentEge Üniversitesien_US
dc.description.abstractMammalian target of rapamycin (mTOR) is a member of the PI3K/Akt/mTOR signaling pathway that participates in cell growth, proliferation, protein synthesis, transcription, angiogenesis, apoptosis and autophagy. We investigated the role of mTOR and other signaling molecules in the rat uterus during implantation. Female pregnant rats were divided into three groups: embryonic days (ED) 4.5, 5.5 and 6.5 according to vaginal smears. Immunohistochemical staining of mTORC1, mTORC2, IGF1, PI3K, pAkt1/2/3, ERK1 and pERK1/2 was performed on formalin fixed, paraffin embedded uterine tissue samples. pAkt1/2/3 and ERK1 also were analyzed using western blotting. We found that PI3K/Akt/mTOR and ERK/pERK were increased during the implantation period. Different amounts of mTORC1, mTORC2, IGF1, PI3K, pAKT1/2/3, ERK1 and pERK1/2 were expressed in luminal epithelium, decidual cells, embryoblast and trophoblast cells during implantation. We suggest that mTOR and associated signaling molecules may participate in implantation.en_US
dc.description.sponsorshipCelal Bayar University, Scientific Research Project Committee [2011/038]en_US
dc.description.sponsorshipOur research was funded by Celal Bayar University, Scientific Research Project Committee, number 2011/038. This research was a poster presentation at the 38th FEBS Congress, July 6-11, 2013 in St. Petersburg, Russia.en_US
dc.identifier.doi10.1080/10520295.2017.1350749en_US
dc.identifier.endpage458en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue6en_US
dc.identifier.pmid28857630en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage450en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2017.1350749
dc.identifier.urihttps://hdl.handle.net/11454/32821
dc.identifier.volume92en_US
dc.identifier.wosWOS:000413865800009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectERK1en_US
dc.subjectimplantationen_US
dc.subjectmTORC1en_US
dc.subjectmTORC2en_US
dc.subjectpAKT1en_US
dc.subject2en_US
dc.subject3en_US
dc.subjectraten_US
dc.titleAssessment of mTOR pathway molecules during implantation in ratsen_US
dc.typeArticleen_US

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