Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

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dc.authoridBedir, Erdal/0000-0003-1262-063X
dc.authoridKUCUKSOLAK, MELIS/0000-0003-1619-4850
dc.authorscopusid37664360600
dc.authorscopusid57205744287
dc.authorscopusid55811426600
dc.authorscopusid7003998497
dc.authorwosidBedir, Erdal/ABI-3895-2020
dc.contributor.authorAksoy, Semiha Cetinel
dc.contributor.authorKucuksolak, Melis
dc.contributor.authorUzel, Atac
dc.contributor.authorBedir, Erdal
dc.date.accessioned2023-01-12T20:12:24Z
dc.date.available2023-01-12T20:12:24Z
dc.date.issued2021
dc.departmentN/A/Departmenten_US
dc.description.abstract7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D-(H-1 and C-13 NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [109S361]; EBILTEM [2012/BIL/028]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 109S361) and EBILTEM (2012/BIL/028).en_US
dc.identifier.doi10.25135/rnp.203.20.08.1766
dc.identifier.endpage607en_US
dc.identifier.issn1307-6167
dc.identifier.issn1307-6167en_US
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85108653316en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage602en_US
dc.identifier.urihttps://doi.org/10.25135/rnp.203.20.08.1766
dc.identifier.urihttps://hdl.handle.net/11454/78299
dc.identifier.volume15en_US
dc.identifier.wosWOS:000658306500015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords Of Natural Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMarine actinobacteriumen_US
dc.subjectStreptomyces cacaoien_US
dc.subjectbenzodiazepineen_US
dc.subjectantimicrobial activityen_US
dc.subjectantibioticsen_US
dc.subjectDnaen_US
dc.subjectPyrrolobenzodiazepineen_US
dc.subjectBiosynthesisen_US
dc.subjectConstituentsen_US
dc.titleBenzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034en_US
dc.typeArticleen_US

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