Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034
Küçük Resim Yok
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acg Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D-(H-1 and C-13 NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.
Açıklama
Anahtar Kelimeler
Marine actinobacterium, Streptomyces cacaoi, benzodiazepine, antimicrobial activity, antibiotics, Dna, Pyrrolobenzodiazepine, Biosynthesis, Constituents
Kaynak
Records Of Natural Products
WoS Q Değeri
Q3
Scopus Q Değeri
N/A
Cilt
15
Sayı
6
