Nanoconjugated materials as sensors in point-of-care diagnostic tools: Detection of small molecules and viruses

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dc.authorscopusid57188963997
dc.authorscopusid57199103659
dc.authorscopusid57564391200
dc.authorscopusid6602258835
dc.authorscopusid6701638388
dc.contributor.authorMoulahoum, H.
dc.contributor.authorGhorbanizamani, F.
dc.contributor.authorGuler, Celik, E.
dc.contributor.authorZihnioglu, F.
dc.contributor.authorTimur, S.
dc.date.accessioned2024-08-25T18:32:30Z
dc.date.available2024-08-25T18:32:30Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractDiagnostic point of care (POC) tools have seen important advances through the many materials introduced to enhance and validate their wide range applications. One of the most used POC tools are paper-based colorimetric formats. These POC are generally based on the use of antibody-antigen pairs interaction for the detection. However, small molecules can be a challenge for these formats and drastically reduce the sensitivity of POC. Therefore, novel conjugated materials using nanoparticles, polymers, and other composites have been developed which helped to tackle the sensitivity issues and, by using these materials, the portable sensors became more trustworthy for the detection of small molecules. These materials can be sculpted into various nanostructures and networks such as nanovesicles and nanogels with high biocompatibility and tunability. These are regarded as promising tools in the current and future lab-on-chip devices due to their accessibility and ease to manufacturing. In addition, the application of portable biosensing devices is of great importance in large-scale screenings of viruses including the coronavirus SARS-CoV-2 (responsible for the COVID-19 pandemic) or road control (i.e., substance of abuse). These approaches were made more accessible using smartphone-assisted analyses allowing for the decentralization of diagnosis. In this chapter, we present the latest findings in the development of polymeric-based materials and biosensors aimed for the detection of viruses and small molecules of drug abuse through simplified approaches including colorimetric paper-based assays and electrochemical sensors. The use of nano-scaled bioconjugated materials became an integral component in sensing applications due to their various structural advantages in producing highly sensitive tools that rival bench-top instruments. New developments in material design opened the door for decentralized dispensation of medicines and public protection that allows effective onsite and point-of-care diagnostics. © 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/bs.coac.2023.02.002
dc.identifier.issn0166-526X
dc.identifier.scopus2-s2.0-85148994386en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1016/bs.coac.2023.02.002
dc.identifier.urihttps://hdl.handle.net/11454/100265
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofComprehensive Analytical Chemistryen_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectBiosensorsen_US
dc.subjectFunctionalizationen_US
dc.subjectSubstances of abuseen_US
dc.subjectSurface modificationen_US
dc.subjectVirus infectionen_US
dc.titleNanoconjugated materials as sensors in point-of-care diagnostic tools: Detection of small molecules and virusesen_US
dc.typeBook Chapteren_US

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