Nanoconjugated materials as sensors in point-of-care diagnostic tools: Detection of small molecules and viruses
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier B.V.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diagnostic point of care (POC) tools have seen important advances through the many materials introduced to enhance and validate their wide range applications. One of the most used POC tools are paper-based colorimetric formats. These POC are generally based on the use of antibody-antigen pairs interaction for the detection. However, small molecules can be a challenge for these formats and drastically reduce the sensitivity of POC. Therefore, novel conjugated materials using nanoparticles, polymers, and other composites have been developed which helped to tackle the sensitivity issues and, by using these materials, the portable sensors became more trustworthy for the detection of small molecules. These materials can be sculpted into various nanostructures and networks such as nanovesicles and nanogels with high biocompatibility and tunability. These are regarded as promising tools in the current and future lab-on-chip devices due to their accessibility and ease to manufacturing. In addition, the application of portable biosensing devices is of great importance in large-scale screenings of viruses including the coronavirus SARS-CoV-2 (responsible for the COVID-19 pandemic) or road control (i.e., substance of abuse). These approaches were made more accessible using smartphone-assisted analyses allowing for the decentralization of diagnosis. In this chapter, we present the latest findings in the development of polymeric-based materials and biosensors aimed for the detection of viruses and small molecules of drug abuse through simplified approaches including colorimetric paper-based assays and electrochemical sensors. The use of nano-scaled bioconjugated materials became an integral component in sensing applications due to their various structural advantages in producing highly sensitive tools that rival bench-top instruments. New developments in material design opened the door for decentralized dispensation of medicines and public protection that allows effective onsite and point-of-care diagnostics. © 2023 Elsevier B.V.
Açıklama
Anahtar Kelimeler
Biosensors, Functionalization, Substances of abuse, Surface modification, Virus infection
Kaynak
Comprehensive Analytical Chemistry
WoS Q Değeri
Scopus Q Değeri
N/A
