Yenidoğan Yoğun Bakım Ünitesinde Nekrotizan Enterokolit Sıklığı ve Özelliklerinin Değerlendirilmesi
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışma nekrotizan enterokolit (NEK) tanısı ile izlenen olgularda hastalığın risk faktörleri, karakteristik özellikleri, klinik, laboratuvar bulguları ve mortalite oranının değerlendirilmesi amacıyla yapılmıştır.Gereç ve Yöntemler: Çalışmaya 2010-2011 yıllarında kliniğimizde izlenen 488 hasta yenidoğan içinde NEK tanısı alan 37 bebek dahil edilmiştir.Bulgular: NEK sıklığı tüm yatan hasta popülasyonunda %7,5 olarak bulundu. NEK olgularında ortalama gebelik yaşı, 27,5±2,5 hafta, ortalama doğum ağırlığı, 1044±485 gram idi ve NEK'li olguların %90'ı <1500 gr ve 30 hafta altında doğmuştu. Yirmi dört olgu evre 1, 13 olgu evre 2-3 olarak sınıflandırıldı. Çok düşük doğum ağırlıklı bebeklerde evre 2-3 NEK %9,8 sıklıkla görüldü. Bebeklerin ortalama gebelik haftası, doğum ağırlığı, cinsiyet, doğum şekli, Apgar skorları, patent duktus arteriozus varlığı ve tedavisi, intrauterin büyüme kısıtlılığı, prematüre retinopatisi, Respiratuvar distres sendromu, intrakraniyal kanama varlığı ile NEK evreleri arasında fark bulunmadı. Evre 2-3 olgularının altısında gastrointestinal perforasyon gelişti. Evre 2-3 NEK olguları evre 1 NEK olguları ile karşılaştırıldığında; trombosit ve hematokrit değerlerinin anlamlı olarak daha düşük (p<0,01 ve p=0,02), mortalitenin daha yüksek olduğu görüldü (p=0,02).Sonuç: NEK gelişen olgularda çok düşük doğum ağırlığı ve gebelik haftası olduğu ve anemi, lökopeni, lökositoz, trombositopeni ve C-reaktif protein yüksekliği gibi laboratuvar bulgularının hastalığın ciddiyeti ile ilişkili olduğu gözlendi. İleri evre, cerrahi gerektiren olgularda ve özellikle de küçük bebeklerde mortalite riski yüksektir.
Aim: the aim of this study was to evaluate the risk factors, characteristic features, clinical and laboratory findings and mortality rates of necrotizing enterocolitis (NEC) patients.Materials and Methods: Thirty seven patients diagnosed with NEC among the 488 cases followed up in our clinic between 2010-2011 were included into this study.Results: the incidence of NEC was found as 7.5% among the total patient population. Mean gestational age and birth weight of NEC patients were 27.5±2.5 weeks and 1044±485 grams. Ninety percent of NEC patients were born under 1500 grams and 30 weeks. Twenty-four cases were classified as stage 1, and 13 cases were classified as stage 2-3. Stage 2-3 NEC was diagnosed in 9.8% of very low birth weight infants. the mean gestational age, birth weight, gender, delivery type, Apgar scores and the incidence of intrauterine growth restriction, diagnosis and/or treatment of patent ductus arteriosus, retinopathy of prematurity, respiratory distress syndrome, intracranial hemorrhage were similar between patients with different stages of NEC. Gastrointestinal perforation developed in six of the stage 2-3 cases. Platelet count and hematocrit levels were lower (p<0.01 and p=0.02); mortality rate was higher (p=0.02) in stage 2-3 patients when compared to stage 1 patients. Conclusion: NEC is more common in newborns with low birth weight and low gestational age. the severity of the illness is closely associated with laboratory abnormalities such as anemia, leucopenia, leukocytosis, thrombocytopenia and elevated C-reactive protein levels. Mortality risk is higher in advanced stages of the disease requiring surgery, and especially small babies.
Aim: the aim of this study was to evaluate the risk factors, characteristic features, clinical and laboratory findings and mortality rates of necrotizing enterocolitis (NEC) patients.Materials and Methods: Thirty seven patients diagnosed with NEC among the 488 cases followed up in our clinic between 2010-2011 were included into this study.Results: the incidence of NEC was found as 7.5% among the total patient population. Mean gestational age and birth weight of NEC patients were 27.5±2.5 weeks and 1044±485 grams. Ninety percent of NEC patients were born under 1500 grams and 30 weeks. Twenty-four cases were classified as stage 1, and 13 cases were classified as stage 2-3. Stage 2-3 NEC was diagnosed in 9.8% of very low birth weight infants. the mean gestational age, birth weight, gender, delivery type, Apgar scores and the incidence of intrauterine growth restriction, diagnosis and/or treatment of patent ductus arteriosus, retinopathy of prematurity, respiratory distress syndrome, intracranial hemorrhage were similar between patients with different stages of NEC. Gastrointestinal perforation developed in six of the stage 2-3 cases. Platelet count and hematocrit levels were lower (p<0.01 and p=0.02); mortality rate was higher (p=0.02) in stage 2-3 patients when compared to stage 1 patients. Conclusion: NEC is more common in newborns with low birth weight and low gestational age. the severity of the illness is closely associated with laboratory abnormalities such as anemia, leucopenia, leukocytosis, thrombocytopenia and elevated C-reactive protein levels. Mortality risk is higher in advanced stages of the disease requiring surgery, and especially small babies.
Açıklama
Anahtar Kelimeler
Pediatri
Kaynak
The Journal of Pediatric Research
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
4
