Evaluation of preimplantation genetic aneuploidy screening cases at a reference i genetics center: 10 years' experience

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dc.contributor.authorDurmaz B.
dc.contributor.authorKaraca E.
dc.contributor.authorTavmergen Goker E.N.
dc.contributor.authorTavmergen E.
dc.contributor.authorSahn G.
dc.contributor.authorAkdogan A.
dc.contributor.authorYasar B.R.
dc.contributor.authorGunduz C.
dc.contributor.authorÖzkınay F.
dc.date.accessioned2019-10-26T21:19:09Z
dc.date.available2019-10-26T21:19:09Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractEvaluation of preimplantation genetic aneuploidy screening cases at a reference genetics center: 10years' experience: The aim of this study is to review and evaluate our preimplantation genetic screening (PGS) records in terms of their demographic data, indications, cytogenetic results, pregnancy outcomes and discuss these findings in different aspects. PGS was performed in a total of 84 couples (87 cycles) between the period 2005 to 2015. Biopsied biastomeres from embryos on day 3 were fixed and fluorescence in situ hybridization was carried out for chromosomes 13, 16, 18, 21, 22, X and Y depending on the indication. The diagnostic and clinical data were retrospectively evaluated. A total of450 biastomeres were biopsied. Ninety-eight of them were found to be suitable for transfer. They were transferred to 72 patients in 75 cycles resulting in 23 pregnancies and 20 healthy births. The most common indication wasjunexplained infertility. The implantation rate was calculated as 23.4% whereas the take-home baby rate was 26.6% per transfer. The highest rate of healthy living births is achieved in patients having low grade maternal mosaic sex chromosomal aneuploidy. All living births achieved by PGS had normal chromosomal structure which we can propose it as an alternative test for couples at risk to select normal embryos to improve the outcomes of assisted reproductive procedures and to avoid the transfer of chromosomally unbalanced and multiple embryos.en_US
dc.identifier.endpage470en_US
dc.identifier.issn1015-8146
dc.identifier.issue4en_US
dc.identifier.pmid30226964en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage461en_US
dc.identifier.urihttps://hdl.handle.net/11454/16609
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditions Medecine et Hygieneen_US
dc.relation.ispartofGenetic Counselingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneuploidyen_US
dc.subjectGenetic testingen_US
dc.subjectPreimplantation genetic screeningen_US
dc.titleEvaluation of preimplantation genetic aneuploidy screening cases at a reference i genetics center: 10 years' experienceen_US
dc.typeArticleen_US

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