Rare cause of weight loss in a kidney transplant recipient: Iron overload

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dc.contributor.authorYaprak M.
dc.contributor.authorÇeltik A.
dc.contributor.authorTuran I.
dc.contributor.authorNart D.
dc.contributor.authorTuran M.N.
dc.contributor.authorSezer T.Ö.
dc.contributor.authorHoşçoşkun C.
dc.contributor.authorTöz H.
dc.date.accessioned2019-10-27T08:21:54Z
dc.date.available2019-10-27T08:21:54Z
dc.date.issued2014
dc.departmentEge Üniversitesien_US
dc.description.abstractVarious reasons such as malignancies and chronic infections may cause weight loss in kidney transplant patients. In this report, iron overload as a rare cause of weight loss in a kidney transplant patient is presented. Forty-seven-year-old male patient who transplanted from a deceased donor 5 years ago was hospitalized because of 20kg of weight loss. In medical history, he had history of hemodialysis for 89 months and received 100-300mg of intravenous iron therapy per week before transplantation and transfused eight units of blood. In physical examination, weight and height were 45kg and 185cm, respectively. Respiratory and cardiac auscultation was normal. Laboratory results revealed as follow: glucose 76mg/dL, urea 60mg/dL, creatinine 1.35mg/dL, aspartate aminotransferase 74U/L, alanine aminotransferase 77U/L, C-reactive protein 2.59mg/dL, albumin 3.3g/dL, globulin 3.4g/dL, white blood cells 3200/mm3, hemoglobin 13.1g/dL and platelets 190,000/mm3. Chest and abdominal tomography didn't reveal any pathology. Portal Doppler ultrasound showed signs of early cirrhosis. Viral and autoimmune hepatitis markers were negative. Ferritin was 5300ng/mL and transferrin saturation was 82%. In liver biopsy, hemosiderosis was diagnosed and heterozygous H63D gene mutation was detected. Totally, 19 units of phlebotomy were performed. Liver function tests and serum ferritin decreased gradually. At outpatient follow-up in 6 months, he returned to former weight. In conclusion, there can be several causes of weight loss in kidney transplant patients. Iron overload can come across as a rare cause of weight loss. In these patients, ferritin levels should be checked and diagnosis should be clarified by liver biopsy and gene mutation analysis. © 2014 Informa Healthcare USA, Inc.en_US
dc.identifier.doi10.3109/0886022X.2013.832860en_US
dc.identifier.endpage122en_US
dc.identifier.issn0886-022X
dc.identifier.issue1en_US
dc.identifier.pmid24059653en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.3109/0886022X.2013.832860
dc.identifier.urihttps://hdl.handle.net/11454/26137
dc.identifier.volume36en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIron overloaden_US
dc.subjectKidney transplantationen_US
dc.subjectPhlebotomyen_US
dc.subjectWeight lossen_US
dc.titleRare cause of weight loss in a kidney transplant recipient: Iron overloaden_US
dc.typeArticleen_US

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