Clinical and Laboratory Findings of SARS-CoV-2 Infection in Children Younger than 6 Months Old: Neutropenia is More Common Not Lymphopenia

Basit Öğe Kaydı
dc.authoridGüner Özenen, Gizem/0000-0002-9725-7501
dc.authorscopusid57221502271
dc.authorscopusid38061964200
dc.authorscopusid57222327020
dc.authorscopusid57222317768
dc.authorscopusid57221276715
dc.authorscopusid56395283800
dc.authorscopusid35611300300
dc.authorwosidGüner Özenen, Gizem/ABG-2316-2021
dc.contributor.authorOzenen, Gizem Guner
dc.contributor.authorBal, Zumrut Sahbudak
dc.contributor.authorBilen, Nimet Melis
dc.contributor.authorArslan, Sema Yildirim
dc.contributor.authorAk, Gunes
dc.contributor.authorKoc, Gonca
dc.contributor.authorCicek, Candan
dc.date.accessioned2023-01-12T20:00:37Z
dc.date.available2023-01-12T20:00:37Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractBackground Studies on age-related differences in clinical and laboratory features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. We aimed to evaluate the demographic, clinical, laboratory findings of SARS-CoV-2 infection in children younger than 6 months old and compare them with older children. Methods A single-center retrospective study, including 209 confirmed SARS-CoV-2 infection cases, was conducted between 11 March 2020 and 1 September 2021. The case group consisted of 47 patients younger than 6 months old, whereas the control group consisted of 162 patients older than 6 months old. Results The mean age of the case group was 2.77 +/- 1.52 months, and the control group was 101.89 +/- 65.77 months. Cough was statistically higher in the control group, and poor feeding was higher in the case group (p = 0.043, 0.010). The underlying disease rate was statistically higher in the control group; however, the hospitalization rate was higher in the case group (p = 0.036, 0.001). The case group had significantly lower median values of the absolute neutrophil count, hemoglobin and higher median values of white blood cell, absolute lymphocyte count and platelet than the control group (p < 0.05). C-reactive protein, fibrinogen values were significantly lower, and procalcitonin, D-dimer, troponin T, N-terminal pro-B-type natriuretic peptide significantly higher in the case group (p < 0.05). Lymphopenia was more common in the control group, whereas neutropenia was more common in the case group (p = 0.001, 0.011). Conclusions We showed that most children younger than 6 months old had mild and asymptomatic SARS-CoV-2 infection; however, the hospitalization rate was higher, and neutropenia was more common in older children. Lay summary Studies on age-related differences in clinical and laboratory features on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pediatric patients are limited. We aimed to evaluate the demographic, clinical and laboratory findings of SARS-CoV-2 infection in children younger than 6 months old and compare them with older children. A single-center retrospective study was conducted, including 209 SARS-CoV-2 infection cases. The case group consisted of 47 patients younger than 6 months old, and the control group consisted of 162 patients older than 6 months old. Most children younger than 6 months old had mild and asymptomatic SARS-CoV-2 infection; however, the hospitalization rate was higher than older children. Neutropenia was more common in patients younger than 6 months than older children with SARS-CoV-2 infection, even if underlying diseases were excluded.en_US
dc.identifier.doi10.1093/tropej/fmac041
dc.identifier.issn0142-6338
dc.identifier.issn1465-3664
dc.identifier.issue3en_US
dc.identifier.pmid35608318en_US
dc.identifier.scopus2-s2.0-85131701766en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1093/tropej/fmac041
dc.identifier.urihttps://hdl.handle.net/11454/77362
dc.identifier.volume68en_US
dc.identifier.wosWOS:000805850500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofJournal of Tropical Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectchildrenen_US
dc.subjectneutropeniaen_US
dc.titleClinical and Laboratory Findings of SARS-CoV-2 Infection in Children Younger than 6 Months Old: Neutropenia is More Common Not Lymphopeniaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu