Diffusion tensor imaging findings in children with sluggish cognitive tempo comorbid Attention Deficit Hyperactivity Disorder

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dc.contributor.authorUnsel-Bolat, Gul
dc.contributor.authorBaytunca, Muharrem Burak
dc.contributor.authorKardas, Burcu
dc.contributor.authorIpci, Melis
dc.contributor.authorIzmir, Sevim Berrin Inci
dc.contributor.authorOzyurt, Onur
dc.contributor.authorErcan, Eyup Sabri
dc.date.accessioned2020-12-01T11:59:22Z
dc.date.available2020-12-01T11:59:22Z
dc.date.issued2020
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective:The construct of Sluggish Cognitive Tempo (SCT) is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. Our main goal was to explore neuropsychological differences in Attention Deficit Hyperactivity Disorder-Inattentive presentation (ADHD-IA) groups with and without SCT symptoms compared to healthy controls. After detecting specific neuropsychological differences, we examined white matter microstructure using Diffusion Tensor Imaging (DTI) data obtained from 3.0 Tesla MRI scans of the cases with SCT symptoms comparing to Typically Developing (TD) controls. Method:In this study, we included 24 cases in the ADHD-IA group with SCT symptoms, 57 cases in the ADHD-IA group without SCT symptoms and, 24 children in the TD group. We applied tract-based spatial statistics to the DTI measures for obtaining fractional anisotropy (FA), axial, radial and mean diffusivity (AD, RD, MD) to explore white matter differences for the whole brain. Results:Omission error scores and longer reaction time scores were specifically associated with inattention symptoms. Commission error scores were significantly and specifically related to SCT symptoms. Cases with SCT symptoms presented increased FA in the bilateral anterior and posterior limb of the internal capsule, bilateral cerebral peduncle, and the fornix than TD group. Conclusions:Neurobiological differences in ADHD cases are still relatively unexplored. We suggest that including an assessment for SCT in the neuropsychological and neuroimaging studies of ADHD may provide more consistent results.en_US
dc.description.sponsorshipEge University Scientific Research Projects Coordination UnitEge University [2016-TIP-047]en_US
dc.description.sponsorshipThis study was supported by Ege University Scientific Research Projects Coordination Unit (Project Number: 2016-TIP-047).en_US
dc.identifier.doi10.1080/08039488.2020.1772364en_US
dc.identifier.endpage626en_US
dc.identifier.issn0803-9488
dc.identifier.issn1502-4725
dc.identifier.issue8en_US
dc.identifier.pmid32543999en_US
dc.identifier.scopus2-s2.0-85086915644en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage620en_US
dc.identifier.urihttps://doi.org/10.1080/08039488.2020.1772364
dc.identifier.urihttps://hdl.handle.net/11454/62240
dc.identifier.volume74en_US
dc.identifier.wosWOS:000544583300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofNordic Journal of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSCTen_US
dc.subjectNeuroimagingen_US
dc.subjectDTIen_US
dc.subjectInternal capsuleen_US
dc.subjectcommission errorsen_US
dc.titleDiffusion tensor imaging findings in children with sluggish cognitive tempo comorbid Attention Deficit Hyperactivity Disorderen_US
dc.typeArticleen_US

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