Does mannose-binding lectin have a role in adult turkish patients with nasal polyposis?

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dc.contributor.authorEren E.
dc.contributor.authorMidilli R.
dc.contributor.authorKaraca E.
dc.contributor.authorOnay H.
dc.contributor.authorKarci B.
dc.contributor.authorÖzkınay C.
dc.date.accessioned2019-10-26T21:47:19Z
dc.date.available2019-10-26T21:47:19Z
dc.date.issued2012
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective. Mannose-binding lectin is an important component of innate immunity; it initiates the lectin pathway of complement activation critical for innate immunity. Failure of local innate defenses may result in defective responses that lead to the persistent carriage of microorganisms or ongoing inflammation. This study investigated the role of mannosebinding lectin levels and the frequency of the 6 functional mannose-binding lectin polymorphisms in Turkish individuals with nasal polyposis. Study Design. A case-control study. Setting. University hospital. Subjects and Methods. Fifty-one patients with nasal polyposis and 53 healthy controls were enrolled. Serum mannosebinding lectin levels were obtained by enzyme-linked immunosorbent assay (ELISA) using the mannose-binding lectin oligomer ELISA kit. Mannose-binding lectin 2 genotyping was performed by isolating the genomic DNA from leukocytes. Results. Mean mannose-binding lectin levels were 1693.2 and 1887.8 in the patient and control group, respectively. Although mannose-binding lectin levels were lower in the patient group, the difference was not statistically significant (P > .05). No overall association was observed between the mannosebinding lectin genotype and susceptibility to nasal polyposis (95% confidence interval = 0.716-4.389, odds ratio = 1.773). The mutant allele frequencies of the 3 structural polymorphisms did not differ significantly between the nasal polyposis patients and the controls (P = .659). Conclusions. Mannose-binding lectins are not involved in the pathogenesis of nasal polyposis in adult Turkish patients, but additional research is needed for further comment. © 2012 American Academy of Otolaryngology - Head and Neck Surgery Foundation.en_US
dc.identifier.doi10.1177/0194599812436945en_US
dc.identifier.endpage84en_US
dc.identifier.issn0194-5998
dc.identifier.issue1en_US
dc.identifier.pmid22301105en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1177/0194599812436945
dc.identifier.urihttps://hdl.handle.net/11454/18602
dc.identifier.volume147en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofOtolaryngology - Head and Neck Surgery (United States)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectinnate immunityen_US
dc.subjectmannose-binding lectinen_US
dc.subjectMBLen_US
dc.subjectnasal polyposisen_US
dc.subjectpathogenesisen_US
dc.subjectTurkishen_US
dc.titleDoes mannose-binding lectin have a role in adult turkish patients with nasal polyposis?en_US
dc.typeArticleen_US

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