High levels of lipid peroxides and vitamin E in spermatic veins of patients with primary varicocele

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dc.contributor.authorBülent Semerci
dc.contributor.authorNevbahar Turgan
dc.contributor.authorMehmet Dündar
dc.contributor.authorSara Habif
dc.contributor.authorEmin Özbek
dc.contributor.authorErdal Apaydın
dc.contributor.authorNecmettin Çıkılı
dc.contributor.authorOya Bayındır
dc.date.accessioned2019-10-26T19:53:11Z
dc.date.available2019-10-26T19:53:11Z
dc.date.issued1996
dc.departmentEge Üniversitesien_US
dc.description.abstractMechanisms leading to impairment of spermatogenesis by varicocele have been subject of much debate. This study was designed to introduce a new insight into the possible pathophysiological mechanisms of male infertility. In 23 patients who underwent high ligation of the spermatic vein (ages 18-38 years ) and in 18 controls (ages 22-56 years ), LPO (lipid peroxides), GSH (reduced glutathione) and vitamin E were determined in peripheral blood drawn preoperatively and in spermatic vein samples . LPO and vitamin E contents in the spermatic veins of varicocele patients were greater than in peripheral blood samples of the same patients (mean ± SEM, peripheral and spermatic, respectively; LPO: 3.32 + 0.26 nmol/mL and 4.22 ± 0.24 nmol/mL (p< 0.01), vitamin E: 1.41 ± 0.13 mg/dL and 1.81 ± 0.11mg/dL (p< 0.05). Neither of the measured parameters exhibited significant differences between peripheral and spermatic blood samples in controls nor did any differ between controls and varicocele patients. Impaired spermatogenesis in varicocele may derive from accelerated free radical generation and subsequent alterations in LPO and some antioxidants due to local hypoxia , as a result of decreased testicular blood flowen_US
dc.description.abstractMechanisms leading to impairment of spermatogenesis by varicocele have been subject of much debate. This study was designed to introduce a new insight into the possible pathophysiological mechanisms of male infertility. In 23 patients who underwent high ligation of the spermatic vein (ages 18-38 years ) and in 18 controls (ages 22-56 years ), LPO (lipid peroxides), GSH (reduced glutathione) and vitamin E were determined in peripheral blood drawn preoperatively and in spermatic vein samples . LPO and vitamin E contents in the spermatic veins of varicocele patients were greater than in peripheral blood samples of the same patients (mean ± SEM, peripheral and spermatic, respectively; LPO: 3.32 + 0.26 nmol/mL and 4.22 ± 0.24 nmol/mL (p< 0.01), vitamin E: 1.41 ± 0.13 mg/dL and 1.81 ± 0.11mg/dL (p< 0.05). Neither of the measured parameters exhibited significant differences between peripheral and spermatic blood samples in controls nor did any differ between controls and varicocele patients. Impaired spermatogenesis in varicocele may derive from accelerated free radical generation and subsequent alterations in LPO and some antioxidants due to local hypoxia , as a result of decreased testicular blood flowen_US
dc.identifier.endpage80en_US
dc.identifier.issn1017-7698
dc.identifier.issue3-4en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRFek1UYzM=
dc.identifier.urihttps://hdl.handle.net/11454/13793
dc.identifier.volume6en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofMedical Journal of Ege Universityen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenel ve Dahili Tıpen_US
dc.titleHigh levels of lipid peroxides and vitamin E in spermatic veins of patients with primary varicoceleen_US
dc.typeOtheren_US

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