Antioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipine

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dc.contributor.authorSozmen, EY
dc.contributor.authorKerry, Z
dc.contributor.authorUysal, F
dc.contributor.authorYetik, G
dc.contributor.authorYasa, M
dc.contributor.authorUstunes, L
dc.contributor.authorOnat, T
dc.date.accessioned2019-10-27T18:23:46Z
dc.date.available2019-10-27T18:23:46Z
dc.date.issued2000
dc.departmentEge Üniversitesien_US
dc.description.abstractThere is a large body of literature describing the causative role of oxidative stress mediated by increased levels of reactive oxygen species in the pathogenesis of cardiovascular disease such as atherosclerosis, hypertension, and restenosis after angioplasty. The positioning of a soft silicone collar around the rabbit carotid artery elicits intimal thickening. The findings from recent studies demonstrated that both intimal thickening and atherosclerosis lead to synthesis of inducible nitric oxide synthase, resulting in abundant amounts of nitric oxide. We investigated the effects of collaring and nicardipine treatment on the activities of antioxidant enzymes, superoxide dismutase and catalase, and total nitrite/nitrate levels, stable products of nitric oxide. Placing the collar increased the total nitrite/nitrate levels and decreased superoxide dismutase activity in collared arteries. Treatment with nicardipine (20 mg/kg/day, s.c.) prevented enhanced nitric oxide degradation without affecting superoxide dismutase and catalase activities. Our results suggest that enhanced nitric oxide production and superoxide anion are generated in response to the collaring, resulting in oxidative stress within the segment in this model.en_US
dc.identifier.doi10.1515/CCLM.2000.004en_US
dc.identifier.endpage25en_US
dc.identifier.issn1434-6621
dc.identifier.issue1en_US
dc.identifier.pmid10774957en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1515/CCLM.2000.004
dc.identifier.urihttps://hdl.handle.net/11454/36142
dc.identifier.volume38en_US
dc.identifier.wosWOS:000087007400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter & Coen_US
dc.relation.ispartofClinical Chemistry and Laboratory Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcollar modelen_US
dc.subjectoxidative stressen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectcatalaseen_US
dc.subjectnitric oxideen_US
dc.subjectnicardipineen_US
dc.titleAntioxidant enzyme activities and total nitrite/nitrate levels in the collar model. Effect of nicardipineen_US
dc.typeArticleen_US

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