Cortical thickness and VBM in young women at risk for familial depression and their depressed mothers with positive family history

Basit Öğe Kaydı
dc.contributor.authorOzalay, Ozgun
dc.contributor.authorAksoy, Burcu
dc.contributor.authorTunay, Sebnem
dc.contributor.authorSimsek, Fatma
dc.contributor.authorChandhoki, Swati
dc.contributor.authorKitis, Omer
dc.contributor.authorEker, Cagdas
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T23:09:26Z
dc.date.available2019-10-27T23:09:26Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractIt has been demonstrated that compared to low-risk subjects, high-risk subjects for depression have structural and functional alterations in their brain scans even before the disease onset. However, it is not known if these alterations are related to vulnerability to depression or epiphenomena. One way to resolve this ambiguity is to detect the structural alterations in the high-risk subjects and determine if the same alterations are present in the probands. In this study, we recruited 24 women with the diagnosis of Major Depressive Disorder (MDD) with recurrent episodes and their healthy daughters (the high-risk for familial depression group; HRFD). We compared structural brain scans of the patients and HRFG group with those of 24 age-matched healthy mothers and their healthy daughters at similar ages to the HRFD group; respectively. Both cortical gray matter (GM) volume and thickness analyses revealed that HRFD daughters and their MDD mothers had similar GM differences in two regions: the right temporoparietal region and the dorsomedial prefrontal cortex. These results suggested that the observed alterations may be related to trait clinical and neurophysiological characteristics of MDD and may present before the onset of illness. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109S134]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (Project Number 109S134).en_US
dc.identifier.doi10.1016/j.pscychresns.2016.04.004en_US
dc.identifier.endpage9en_US
dc.identifier.issn0925-4927
dc.identifier.issn1872-7506
dc.identifier.pmid27136662en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2016.04.004
dc.identifier.urihttps://hdl.handle.net/11454/52647
dc.identifier.volume252en_US
dc.identifier.wosWOS:000377354600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Research-Neuroimagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectHigh-risk for depressionen_US
dc.subjectVoxel-based morphometryen_US
dc.subjectCortical thicknessen_US
dc.subjectTemporoparietal areaen_US
dc.subjectPrefrontal cortexen_US
dc.titleCortical thickness and VBM in young women at risk for familial depression and their depressed mothers with positive family historyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu