Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)

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dc.authorscopusid37002887000
dc.authorscopusid16203384500
dc.authorscopusid57867202100
dc.authorscopusid7005094713
dc.authorscopusid7003953248
dc.authorscopusid56348383300
dc.authorscopusid6603070081
dc.contributor.authorKayikci, Omur
dc.contributor.authorMehtap, Ozgur
dc.contributor.authorSari, Ismail
dc.contributor.authorDemirkan, Fatih
dc.contributor.authorBeyan, Cengiz
dc.contributor.authorCetin, Guven
dc.contributor.authorVural, Filiz
dc.date.accessioned2023-01-12T20:16:53Z
dc.date.available2023-01-12T20:16:53Z
dc.date.issued2022
dc.departmentN/A/Departmenten_US
dc.description.abstractObjective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy.en_US
dc.identifier.doi10.4274/tjh.galenos.2022.2022.0052
dc.identifier.endpage177en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid35678126en_US
dc.identifier.scopus2-s2.0-85137000431en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2022.2022.0052
dc.identifier.urihttps://hdl.handle.net/11454/78787
dc.identifier.volume39en_US
dc.identifier.wosWOS:000883473800003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLymphomasen_US
dc.subjectAutologous stem cell transplantationen_US
dc.subjectT-cell lymphomasen_US
dc.subjectNon-Hodgkin lymphomaen_US
dc.subjectHigh-Dose Chemotherapyen_US
dc.subjectAmerican Societyen_US
dc.subjectUp-Fronten_US
dc.subjectTransplantationen_US
dc.subjectSurvivalen_US
dc.subjectGuidelinesen_US
dc.subjectPrognosisen_US
dc.subjectDiseaseen_US
dc.subjectCohorten_US
dc.titleReal-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)en_US
dc.title.alternativeNon-kutanöz Periferik T-hücreli Lenfomalarda Klinik Özellikler ve Tedavi Sonuçlarına ilişkin Gerçek Yaşam Deneyimi:Türk Hematoloji Araştırma ve Eğitim Grubunun Çok Merkezli Çalışmasıen_US
dc.typeArticleen_US

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