Detection of Helicobacter pylori in bladder biopsy specimens of patients with interstitial cystitis by polymerase chain reaction

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dc.contributor.authorAtuğ F.
dc.contributor.authorTurkeri L.
dc.contributor.authorAtug O.
dc.contributor.authorCal C.
dc.date.accessioned2019-10-27T00:23:02Z
dc.date.available2019-10-27T00:23:02Z
dc.date.issued2004
dc.departmentEge Üniversitesien_US
dc.description.abstractThe cause of interstitial cystitis (IC) is still unknown. Several features suggest that it may be an infectious disease and it has compelling similarities to chronic gastritis. The identification of Helicobacter pylori as the cause of chronic gastritis focused attention on this organism. Many studies have been done investigating the role of H. pylori in the etiology of IC. Previous studies mostly determined the presence of H.pylori with antibodies in the serum samples of IC patients, but these methods may lead to false positive or negative results. We therefore investigated the presence of H. pylori in bladder biopsy specimens by using polymerase chain reaction (PCR), which is accepted as the most sensitive and specific test for detecting this organism. A total of 32 patients with IC were enrolled into the study. The PCR assay was performed on cold cup bladder biopsies of IC patients. Both positive and negative controls were included in each set of PCR reactions. Gastric biopsy specimens of peptic ulcer patients with proven H. pylori infection were used as positive controls. Bladder biopsies of all IC patients were negative for H. pylori DNA. PCR showed the presence of H. pylori in the positive controls in each cycle demonstrating that the PCR assay was working properly. Thus, there is no evidence that IC is the result of H. pylori infection. This study does not negate the possibility that other infectious agents may play a role in the etiology of IC. © Springer-Verlag 2004.en_US
dc.identifier.doi10.1007/s00240-004-0425-7en_US
dc.identifier.endpage349en_US
dc.identifier.issn0300-5623
dc.identifier.issue5en_US
dc.identifier.pmid15146299en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-004-0425-7
dc.identifier.urihttps://hdl.handle.net/11454/22707
dc.identifier.volume32en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHelicobacter pylorien_US
dc.subjectInterstitial cystitisen_US
dc.subjectPolymerase chain reactionen_US
dc.titleDetection of Helicobacter pylori in bladder biopsy specimens of patients with interstitial cystitis by polymerase chain reactionen_US
dc.typeArticleen_US

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