Diethylenetriamine pentaacetic acid derivative of toremifene and in vitro evaluation in human breast cancer cell line MCF-7

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dc.contributor.authorKilcar A.Y.
dc.contributor.authorBiber Muftuler F.Z.
dc.contributor.authorUnak P.
dc.contributor.authorAvci C.B.
dc.contributor.authorGunduz C.
dc.date.accessioned2019-10-27T08:34:04Z
dc.date.available2019-10-27T08:34:04Z
dc.date.issued2011
dc.departmentEge Üniversitesien_US
dc.description.abstractCytotoxic and apoptotic effects of toremifene-diethylenetriamine pentaacetic acid (TOR-DTPA), formed by conjugation of TOR and DTPA, on the MCF-7 cell line were evaluated. TOR-DTPA was synthesized and qualified via gas chromatography-mass spectrometry system, thin layer chromatography, and high performance liquid chromatography methods. To screen the biological properties of TOR-DTPA at determined concentrations, our ongoing effort was to evaluate apoptotic and cytotoxic effects on the MCF-7 cell line. Trypan blue dye exclusion test, XTT, ELISA, and TUNEL assays were utilized to evaluate cytotoxicity and apoptosis. TOR-DTPA has no cytotoxic and limited apoptotic effect on the MCF-7 cell line according to the results of in vitro studies. It is concluded that the lack of obvious apoptotic and cytotoxic effects allows the already proposed ligand, TOR-DTPA, to be improved as a novel hydrophilic ligand for breast imaging. © Copyright 2011, Mary Ann Liebert, Inc.en_US
dc.identifier.doi10.1089/cbr.2010.0860en_US
dc.identifier.endpage111en_US
dc.identifier.issn1084-9785
dc.identifier.issue1en_US
dc.identifier.pmid21355781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.1089/cbr.2010.0860
dc.identifier.urihttps://hdl.handle.net/11454/26959
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofCancer Biotherapy and Radiopharmaceuticalsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast tissueen_US
dc.subjectMCF-7 cell lineen_US
dc.subjectTOR-DTPAen_US
dc.subjecttoremifene (TOR)en_US
dc.titleDiethylenetriamine pentaacetic acid derivative of toremifene and in vitro evaluation in human breast cancer cell line MCF-7en_US
dc.typeArticleen_US

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