Factors influencing engraftment in autologous peripheral hematopoetic stem cell transplantation (PBSCT)

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dc.contributor.authorErgene, Ulku
dc.contributor.authorCagirgan, Seckin
dc.contributor.authorPehlivan, Mustafa
dc.contributor.authorYilmaz, Mumtaz
dc.contributor.authorTombuloglu, Murat
dc.date.accessioned2019-10-27T19:36:41Z
dc.date.available2019-10-27T19:36:41Z
dc.date.issued2007
dc.departmentEge Üniversitesien_US
dc.description.abstractAutologous peripheral blood stem cells transplantation (PBSCT) is a therapeutic option which can be used in various hematological neoplastic disorders; and it can prolong disease free survival and total survival and at times it may be curative. In this study, we investigated variables influencing PBSCT in 91 patients who had undergone PBSCT between 1998 and 2002 in our center, retrospectively. PBSC collection was performed after mobilization with G-CSF or chemotherapy plus growth factor. Only high dose chemotherapy was used for conditioning regimes. The median number of CD34+ was 11.5 x 10(6)/kg. Posttransplant neutrophil engraftment (> 500/mu L) was requiring a median of 10 days, it was 13 days for platelet engraftment (> 20,000/mu L). For neutrophil and platelet engraftment, we investigated; sex, age, diagnosis and CD34+ cells, the time interval between diagnosis and transplantation, number of apheresis, conditioning regime, growth factor initiation day as independent variables. In univariate analysis CD34+ cell number (> 10 x 10(6)/kg), time interval more than one year between diagnosis and transplantation and BEAM conditioning was found to be significant for neutrophil engraftment. But in multivariate analysis none of them was found to be significant. For platelet engraftment in univariate analysis CD34+ cell number (> 7 x 10(6)/kg), primary diagnosis of multiple myeloma initiation day of growth factor (> 2 day) was found to be significant. In multivariate analyses only CD34+ cell count was found to be significant (p = 0.005). In conclusion, as in previous studies we found that the only predictor of engraftment kinetics was CD34+ cell count. (c) 2006 Published by Elsevier Ltd.en_US
dc.identifier.doi10.1016/j.transci.2006.08.009en_US
dc.identifier.endpage29en_US
dc.identifier.issn1473-0502
dc.identifier.issue1en_US
dc.identifier.pmid17292672en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.transci.2006.08.009
dc.identifier.urihttps://hdl.handle.net/11454/39883
dc.identifier.volume36en_US
dc.identifier.wosWOS:000245704500005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofTransfusion and Apheresis Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautologous stem cell transplantationen_US
dc.subjectCD34+cellsen_US
dc.subjectengraftmenten_US
dc.titleFactors influencing engraftment in autologous peripheral hematopoetic stem cell transplantation (PBSCT)en_US
dc.typeArticleen_US

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