Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study

Basit Öğe Kaydı
dc.contributor.authorBellikci-Koyu, Ezgi
dc.contributor.authorSarer-Yurekli, Banu Pinar
dc.contributor.authorAkyon, Yakut
dc.contributor.authorAydin-Kose, Fadime
dc.contributor.authorKaragozlu, Cem
dc.contributor.authorOzgen, Ahmet Gokhan
dc.contributor.authorBuyuktuncer, Zehra
dc.date.accessioned2020-12-01T12:09:26Z
dc.date.available2020-12-01T12:09:26Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionYILMAZ, Engin/0000-0001-8873-7645; Ergunay, Koray/0000-0001-5422-1982; Karagozlu, Cem/0000-0002-2874-4998; Kose, Fadime Aydin/0000-0001-5222-7555; bellikci koyu, ezgi/0000-0001-5279-2394en_US
dc.description.abstractSeveral health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. in a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-alpha, IFN-gamma, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p <= 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition.en_US
dc.description.sponsorshipTurkish Council of Higher EducationMinistry of National Education - Turkeyen_US
dc.description.sponsorshipThis research was funded by the Turkish Council of Higher Education.en_US
dc.identifier.doi10.3390/nu11092089
dc.identifier.issn2072-6643
dc.identifier.issue9en_US
dc.identifier.pmid31487797en_US
dc.identifier.urihttps://doi.org/10.3390/nu11092089
dc.identifier.urihttps://hdl.handle.net/11454/63449
dc.identifier.volume11en_US
dc.identifier.wosWOS:000487964600296en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofNutrientsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectkefiren_US
dc.subjectgut microbiotaen_US
dc.subjectmetabolic syndromeen_US
dc.titleEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu