A Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensics

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dc.contributor.authorAydindogan, Eda
dc.contributor.authorBalaban, Simge
dc.contributor.authorEvran, Serap
dc.contributor.authorCoskunol, Hakan
dc.contributor.authorTimur, Suna
dc.date.accessioned2020-12-01T12:05:58Z
dc.date.available2020-12-01T12:05:58Z
dc.date.issued2019
dc.departmentEge Üniversitesien_US
dc.descriptionEvran, Serap/0000-0001-6676-4888; Aydindogan, Eda/0000-0003-4882-6445; BALABAN, Simge/0000-0002-4540-1882en_US
dc.description.abstractAptamer-based point-of-care (POC) diagnostics platforms may be of substantial benefit in forensic analysis as they provide rapid, sensitive, user-friendly, and selective analysis tools for detection. Aptasensors have not yet been adapted commercially. However, the significance of the applications of aptasensors in the literature exceeded their potential. Herein, in this review, a bottom-up approach is followed to describe the aptasensor development and application procedure, starting from the synthesis of the corresponding aptamer sequence for the selected analyte to creating a smart surface for the sensitive detection of the molecule of interest. Optical and electrochemical biosensing platforms, which are designed with aptamers as recognition molecules, detecting abused drugs are critically reviewed, and existing and possible applications of different designs are discussed. Several potential disciplines in which aptamer-based biosensing technology can be of greatest value, including forensic drug analysis and biological evidence, are then highlighted to encourage researchers to focus on developing aptasensors in these specific areas.en_US
dc.description.sponsorshipRepublic of Turkey, Ministry of DevelopmentTurkiye Cumhuriyeti Kalkinma Bakanligi [2016K121190]en_US
dc.description.sponsorshipResearches were funded by the Republic of Turkey, Ministry of Development, grant number 2016K121190.en_US
dc.identifier.doi10.3390/bios9040118en_US
dc.identifier.issn2079-6374
dc.identifier.issue4en_US
dc.identifier.pmid31581533en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/bios9040118
dc.identifier.urihttps://hdl.handle.net/11454/63125
dc.identifier.volume9en_US
dc.identifier.wosWOS:000505735900018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofBiosensors-Baselen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectpoint-of-care (POC)en_US
dc.subjectcustom-tailored aptamersen_US
dc.subjectoptical biosensorsen_US
dc.subjectelectrochemical biosensorsen_US
dc.subjectforensic sciencesen_US
dc.titleA Bottom-Up Approach for Developing Aptasensors for Abused Drugs: Biosensors in Forensicsen_US
dc.typeReview Articleen_US

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