Toxicity of cephalaria species and their individual constituents against aedes aegypti

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dc.contributor.authorSarikahya N.B.
dc.contributor.authorKayce P.
dc.contributor.authorTabanca N.
dc.contributor.authorEstep A.S.
dc.contributor.authorBecnel J.J.
dc.contributor.authorKhan I.A.
dc.contributor.authorKirmizigul S.
dc.date.accessioned2019-10-26T21:26:54Z
dc.date.available2019-10-26T21:26:54Z
dc.date.issued2015
dc.departmentEge Üniversitesien_US
dc.description.abstractCrude acetone and ethanol extracts of the aerial parts of 21 Cephalaria species collected from Turkey were investigated for larvicidal and adult topical activity against Aedes aegypti. The ethanol extracts from C. Elazigensis var. purpurea, C. Anatolica, and C. Elmaliensis possessed the highest mortality against first instar Ae. Aegypti larvae. Luteolin-7-O-ß-D-glycoside (1), isolated from C. Elmaliensis ethanol extract, demonstrated 33% and 53% mortality at 0.1 µg/mL concentration against first instar ORL (susceptible) and PR (pyrethroid resistant) strains, respectively. C. scoparia acetone extract showed 100% mortality against adult Ae. Aegypti. From this extract compounds 2-8 were isolated. Compound 2 (isoorientin) possessed the highest toxicity with 31.7% and 65% mortality at a 10 µg/mL concentration against adult ORL and PR strains, respectively. This is the first screening report of potential insecticides from Cephalaria species against the yellow fever mosquito, Ae. Aegypti, and the active compounds (1 and 2) could lead to the development of a new class of insecticide.en_US
dc.identifier.endpage1198en_US
dc.identifier.issn1934-578X
dc.identifier.issue7en_US
dc.identifier.pmid26411009en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1195en_US
dc.identifier.urihttps://hdl.handle.net/11454/17380
dc.identifier.volume10en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNatural Product Incorporationen_US
dc.relation.ispartofNatural Product Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdult topical activityen_US
dc.subjectAedes aegyptien_US
dc.subjectCephalaria speciesen_US
dc.subjectFlavonoid glycosidesen_US
dc.subjectIridoid glycosidesen_US
dc.subjectLarvidical activityen_US
dc.subjectMosquito controlen_US
dc.titleToxicity of cephalaria species and their individual constituents against aedes aegyptien_US
dc.typeArticleen_US

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