Do Clinical and Immunohistochemical Findings of Pure Mucinous Breast Carcinoma Differ from Mixed Mucinous Breast Carcinoma ?

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dc.contributor.authorErhan, Y.
dc.contributor.authorCiris, M.
dc.contributor.authorZekioglu, O.
dc.contributor.authorErhan, Y.
dc.contributor.authorKapkac, M.
dc.contributor.authorMakay, Oe.
dc.contributor.authorOzdemir, N.
dc.date.accessioned2019-10-27T20:19:05Z
dc.date.available2019-10-27T20:19:05Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractMucinous carcinoma of the breast is a relatively rare histologic type with two subtypes : pure and mixed. It has a favourable prognosis with a low risk of axillary metastases. The prognosis for pure mucinous carcinoma (PMC) was much better than for the mixed mucinous carcinoma (MMC). The aim of the study is to determine suitable candidates for breast or axillary conservation in mucinous carcinoma subtypes. The slides of 26 pure and 23 mixed mucinous carcinomas of the breast were evaluated. The clinical, pathological and immunohistochemical features between PMCs and MMCs were compared. MMC displayed greater metastatic potential (p < 0.05), p53 positivity (p < 0.05) and c-erbB-2 positivity (p < 0.001) than PMCs. PMCs smaller than 2 cm had less metastatic capacity and extranodal invasion compared to MMCs smaller than 2 cm (p < 0.001 and p < 0.01, respectively). MMCs smaller than 2 cm displayed weaker ER positivity but greater c-erbB-2 positivity than PMCs smaller than 2 cm (p < 0.01). In conclusion, MMC had worse prognostic factors than PMC with both types of mucinous carcinoma showing similar ER and PR positive status. Even if PMCs and especially smaller PMCs display more favourable prognostic features, including less axillary lymph node involvement, it is appropriate to use sentinel lymph node biopsy to make better axillary assessment.en_US
dc.identifier.endpage208en_US
dc.identifier.issn0001-5458
dc.identifier.issue2en_US
dc.identifier.pmid19499682en_US
dc.identifier.startpage204en_US
dc.identifier.urihttps://hdl.handle.net/11454/41313
dc.identifier.volume109en_US
dc.identifier.wosWOS:000266210100011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherActa Medical Belgicaen_US
dc.relation.ispartofActa Chirurgica Belgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMucinous breast canceren_US
dc.subjectaxillary node dissectionen_US
dc.subjectbreast carcinomaen_US
dc.titleDo Clinical and Immunohistochemical Findings of Pure Mucinous Breast Carcinoma Differ from Mixed Mucinous Breast Carcinoma ?en_US
dc.typeArticleen_US

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