The aluminum content of intravenous solutions in routine use in Turkey

Basit Öğe Kaydı
dc.contributor.authorMehmet Demircan
dc.contributor.authorCanan Çoker
dc.contributor.authorGeylani Özok
dc.date.accessioned2019-10-26T19:54:20Z
dc.date.available2019-10-26T19:54:20Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractAluminum (Al), an element with no known biological function, has been shown both clinically and experimentally to be toxic to bones, the central nervous system and liver. Aluminum is a contaminant of a number of large and small volume parenterals, most often given intravenously. Since the mid-1970's, reports have been frequently published about Al contamination of intravenous solutions from the United States and Europe. The purpose of this study is to determine the degree of aluminum contamination in total parenteral nutrition (TPN) solutions and other intravenous fluids in routine use in Turkey. Determination of concentration of Al in various solutions (solutions of amino acids, dextrose, lipid emulsions, human albumin, 0.9% sodium chloride (NaCl), potassium chloride (KCl), calcium, magnesium sulfate (MgSO4), vitamin, carnitine, etc.) was performed by inductively coupled argon plasma emisson spectrometry (ICP). We found a high degree of Al contamination in parenterals extending to 356 µg Al/L in amino acid solutions, 1112 µg Al/L in lipid emulsions, 380 µg Al/L dextroses, 2750 µg Al/L in human albumin, 4040 µg Al/L in calcium and 2200 µg Al/L in vitamin C solutions. These Al contents may be regarded as extremely high when compared to the FDA's (Food and Drug Administration) recommendation of setting an upper limit of 25 µg Al/L for all parenterals. Therefore, the amount of Al in TPN and other parenteral solutions used in Turkey should be urgently minimized.en_US
dc.description.abstractAluminum (Al), an element with no known biological function, has been shown both clinically and experimentally to be toxic to bones, the central nervous system and liver. Aluminum is a contaminant of a number of large and small volume parenterals, most often given intravenously. Since the mid-1970's, reports have been frequently published about Al contamination of intravenous solutions from the United States and Europe. The purpose of this study is to determine the degree of aluminum contamination in total parenteral nutrition (TPN) solutions and other intravenous fluids in routine use in Turkey. Determination of concentration of Al in various solutions (solutions of amino acids, dextrose, lipid emulsions, human albumin, 0.9% sodium chloride (NaCl), potassium chloride (KCl), calcium, magnesium sulfate (MgSO4), vitamin, carnitine, etc.) was performed by inductively coupled argon plasma emisson spectrometry (ICP). We found a high degree of Al contamination in parenterals extending to 356 µg Al/L in amino acid solutions, 1112 µg Al/L in lipid emulsions, 380 µg Al/L dextroses, 2750 µg Al/L in human albumin, 4040 µg Al/L in calcium and 2200 µg Al/L in vitamin C solutions. These Al contents may be regarded as extremely high when compared to the FDA's (Food and Drug Administration) recommendation of setting an upper limit of 25 µg Al/L for all parenterals. Therefore, the amount of Al in TPN and other parenteral solutions used in Turkey should be urgently minimized.en_US
dc.identifier.endpage10en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.startpage7en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRNeE56WTI=
dc.identifier.urihttps://hdl.handle.net/11454/14112
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleThe aluminum content of intravenous solutions in routine use in Turkeyen_US
dc.typeOtheren_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu