Regression of endometrial implants by resveratrol in an experimentally induced endometriosis model in rats

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dc.contributor.authorErgenoglu A.M.
dc.contributor.authorYeniel A.O.
dc.contributor.authorErbaş O.
dc.contributor.authorAktug H.
dc.contributor.authorYildirim N.
dc.contributor.authorUlukuş M.
dc.contributor.authorTaskiran D.
dc.date.accessioned2019-10-27T08:23:13Z
dc.date.available2019-10-27T08:23:13Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: To evaluate the effect of resveratrol on an experimentally induced endometriosis rat model. Study design: After endometriotic implants were surgically formed, rats were randomly divided into 2 groups as control group (saline treated, n = 6) and resveratrol group (10 mg/kg/d, n = 6). The inflammatory markers and histopathological changes were assessed at the end of the treatment period. Results Our results showed (1) significant reduction in the implant size (P < .0005); (2) significantly decreased levels of vascular endothelial growth factor (VEGF) in the peritoneal fluid and plasma (P < .005); and monocyte chemotactic protein 1 (MCP-1) in the peritoneal fluid (P < .05), (3) highly significant suppression of VEGF expression in the endometriotic tissue (P < .0005); and (4) considerable histological changes in the endometriotic foci following resveratrol treatment. Conclusion: Resveratrol appears to be effective on the development of endometriosis through its antiangiogenic and anti-inflammatory properties. Future studies with different doses of resveratrol might provide more comprehensive results regarding the treatment of endometriosis. © The Author(s) 2013.en_US
dc.identifier.doi10.1177/1933719113483014en_US
dc.identifier.endpage1236en_US
dc.identifier.issn1933-7191
dc.identifier.issue10en_US
dc.identifier.pmid23536571en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1230en_US
dc.identifier.urihttps://doi.org/10.1177/1933719113483014
dc.identifier.urihttps://hdl.handle.net/11454/26390
dc.identifier.volume20en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofReproductive Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcytokinesen_US
dc.subjectendometriosisen_US
dc.subjectMCP-1en_US
dc.subjectresveratrolen_US
dc.subjectTNF-?en_US
dc.subjectVEGFen_US
dc.titleRegression of endometrial implants by resveratrol in an experimentally induced endometriosis model in ratsen_US
dc.typeArticleen_US

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