Comparison between dynamic susceptibility contrast magnetic resonance imaging and arterial spin labeling techniques in distinguishing malignant from benign brain tumors

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dc.contributor.authorAta, Emine Sevcan
dc.contributor.authorTurgut, Mehmet
dc.contributor.authorEraslan, Cenk
dc.contributor.authorDayanir, Yelda Ozsunar
dc.date.accessioned2019-10-27T23:08:55Z
dc.date.available2019-10-27T23:08:55Z
dc.date.issued2016
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectives: The purpose of this study was to preliminarily compare unenhanced arterial spin-labeled (ASL) imaging, dynamic susceptibility contrast-enhanced cerebral blood volume (DSCE-CBV) magnetic resonance imaging (MRI) for evaluation of tumor perfusion in patients with brain tumors. Materials and methods: A total of 27 patients with brain tumors were examined in 1,5 T MRI. Single phase and multiphase ASL, DSCE-CBV examinations were assessed by both qualitative and quantitative analysis for the detection of malignancy. Imaging results were correlated with a histopathology or follow-up. Results: Based on 31 studies in 27 patients with brain tumors, the visual inspection sensitivities for ASL and dynamic DSC perfusion imaging were 88% and 94%, respectively, with 100% specificity for both. On qualitative evaluation, sensitivities for ASL and DSC perfusion imaging perfusions were 88% and 94%, respectively, with 100% specificity for both. The highest sensitivity values for quantitative ASL imaging were obtained using a normalized cut-off ratio of 1.65, resulting in sensitivity of 94% for ASL imaging and cut-off ratio of 1.95 and sensitivity 94% for DSCE-CBV imaging. Conclusion: The present study revealed similar sensitivity and specificity for both multhiphase ASL and DSC MRI. Thus, we suggest that ASL perfusion can be used in daily clinical practice. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2016.05.015en_US
dc.identifier.endpage1553en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue9en_US
dc.identifier.pmid27501887en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1545en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2016.05.015
dc.identifier.urihttps://hdl.handle.net/11454/52423
dc.identifier.volume85en_US
dc.identifier.wosWOS:000381661700004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArterial spin labelingen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectBrain tumorsen_US
dc.titleComparison between dynamic susceptibility contrast magnetic resonance imaging and arterial spin labeling techniques in distinguishing malignant from benign brain tumorsen_US
dc.typeArticleen_US

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