Comparative assessment of pulsed electromagnetic fields (PEMF) and pulsed radio frequency energy (PRFE) on an in vitro wound healing model

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dc.contributor.authorKaraman, Ozan
dc.contributor.authorGumusay, Mehmet
dc.contributor.authorDemirci, Emine Afra
dc.contributor.authorKaya, Adnan
dc.date.accessioned2019-10-27T10:45:32Z
dc.date.available2019-10-27T10:45:32Z
dc.date.issued2018
dc.departmentEge Üniversitesien_US
dc.description.abstractPulsed electromagnetic fields (PEMF) and pulsed radio frequency energy (PRFE) have been shown to accelerate wound healing process due to its ability to stimulate cellular proliferation. However, comparative efficacy of PEMF and PRFE on an in vitro wound healing study has yet to be studied. The present study examined the effect of PEMF and PRFE on an in vitro wound healing model developed by using 3T3 mouse fibroblasts. Cells were exposed to PEMF (75 Hz frequency, square waveform, and 1-mT magnetic field) and PRFE (27.12 MHz, Phase-shift keying (PSK), and 13-dBm amplitude signal) for 5 hours. The migration rates of 3T3 fibroblasts were determined by capturing images at time points of 0, 12, 24, 48, and 72 hours. Cell proliferation was also quantified. The results of the migration and proliferation assays showed that PEMF and PRFE applied groups had significantly greater cell proliferation and migration compared to control group. In addition, PRFE application showed significantly faster wound area closure compared to PEMF application.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114E490]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) under Grant No 114E490. Authors would like to acknowledge Ege University Research Group of Animal Cell Culture and Tissue Engineering (EgeREACT) for donating 3T3 mouse fibroblasts. Finally, authors would like to thank Bonegraft Biological Materials Co. (Izmir, Turkey) for providing technical assistance in cell culture studies.en_US
dc.identifier.doi10.3233/JAE-170129
dc.identifier.endpage437en_US
dc.identifier.issn1383-5416
dc.identifier.issn1875-8800
dc.identifier.issn1383-5416en_US
dc.identifier.issn1875-8800en_US
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.3233/JAE-170129
dc.identifier.urihttps://hdl.handle.net/11454/31164
dc.identifier.volume57en_US
dc.identifier.wosWOS:000438746900005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIos Pressen_US
dc.relation.ispartofInternational Journal of Applied Electromagnetics and Mechanicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulsed radio frequency energy (PRFE)en_US
dc.subjectpulsed electromagnetic fields (PEMF)en_US
dc.subjectwound healingen_US
dc.subjectrectangular spiral applicatoren_US
dc.titleComparative assessment of pulsed electromagnetic fields (PEMF) and pulsed radio frequency energy (PRFE) on an in vitro wound healing modelen_US
dc.typeArticleen_US

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