Excitatory amino acid levels in cerebrospinal fluids of epileptic patients

Basit Öğe Kaydı
dc.contributor.authorHakan Ebiboğlu
dc.contributor.authorSara Habif
dc.contributor.authorNevbahar Turgan
dc.contributor.authorIşıl Mutaf
dc.contributor.authorCumhur Ertekin
dc.contributor.authorOya Bayındır
dc.date.accessioned2019-10-26T20:04:19Z
dc.date.available2019-10-26T20:04:19Z
dc.date.issued1997
dc.departmentEge Üniversitesien_US
dc.description.abstractEpilepsy is among the most neurologic disorders. Due to its damaging effects on the brain and the psychological problems that it creates in the patients, it deserves extensive study of its pathogenesis and new therapeutical approaches. The most widely accepted hypothesis on the pathogenesis of epilepsy is a failure in the regulation of excitatory and inhibitory mechanisms in the brain. The aim of this study was to assess the levels of amino acids in cerebrospinal fluid (CSF) which was believed to reflect the levels of excitatory amino acids in the brain. CSF glutamate, aspartate and glycine levels were determined by gas -liquid chromatography in 12 epileptic patients (juvenile myoclonic epilepsy (JME) n=7, idiopathic primary generalized epilepsy with tonic clonic seizuren=5) and 12 controls. In the epileptic patients, glutamate and glycine levels were significantly higher than controls (p The findings of this study suggest that further studies with a larger patient population and comparison of levels in CSF and epileptogenic brain tissue would be useful for a better understanding of the role excitatory amino acids in the pathogenesis of epilepsyen_US
dc.description.abstractEpilepsy is among the most neurologic disorders. Due to its damaging effects on the brain and the psychological problems that it creates in the patients, it deserves extensive study of its pathogenesis and new therapeutical approaches. The most widely accepted hypothesis on the pathogenesis of epilepsy is a failure in the regulation of excitatory and inhibitory mechanisms in the brain. The aim of this study was to assess the levels of amino acids in cerebrospinal fluid (CSF) which was believed to reflect the levels of excitatory amino acids in the brain. CSF glutamate, aspartate and glycine levels were determined by gas -liquid chromatography in 12 epileptic patients (juvenile myoclonic epilepsy (JME) n=7, idiopathic primary generalized epilepsy with tonic clonic seizuren=5) and 12 controls. In the epileptic patients, glutamate and glycine levels were significantly higher than controls (p The findings of this study suggest that further studies with a larger patient population and comparison of levels in CSF and epileptogenic brain tissue would be useful for a better understanding of the role excitatory amino acids in the pathogenesis of epilepsyen_US
dc.identifier.endpage242en_US
dc.identifier.issn1300-0144
dc.identifier.issue3en_US
dc.identifier.startpage239en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TkRNeU1qRXg=
dc.identifier.urihttps://hdl.handle.net/11454/14808
dc.identifier.volume27en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryDiğeren_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.titleExcitatory amino acid levels in cerebrospinal fluids of epileptic patientsen_US
dc.typeOtheren_US

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