In vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal models

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dc.authorscopusid16686248800
dc.authorscopusid35956001200
dc.authorscopusid36187604000
dc.authorscopusid57200246789
dc.contributor.authorDurkan, Kübra
dc.contributor.authorİçhedef, Çiğdem
dc.contributor.authorKılçar, Ayfer Yurt
dc.contributor.authorKöksal Karayıldırım, Çinel
dc.date.accessioned2024-08-25T18:36:12Z
dc.date.available2024-08-25T18:36:12Z
dc.date.issued2023
dc.departmentEge Üniversitesien_US
dc.description.abstractObjectiveThe objective of this study was to develop radiolabeled ibuprofen (Tc-99m-ibu) for imaging and discrimination of inflammation and infection and compare its biodistribution in two different animal models.SignificanceThe development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis and management of various inflammatory and infectious diseases. This study provides a promising approach to the detection of sterile infections.MethodsIbuprofen was radiolabeled with Tc-99m using the stannous chloride method with a yield of 99.05 & PLUSMN; 0.83% (n = 5). The in vivo biological behavior of radiolabeled ibuprofen was determined in Wistar albino rat models of sterile inflammation and bacterial infection with Staphylococcus aureus gram-positive bacteria. Biodistribution studies were carried out at different time points, and the results were compared between the two animal models.ResultsThe uptake of Tc-99m-ibu in sterile inflammation sites at all time points was higher than that in the infection sites. This suggests that Tc-99m-ibu can be used to discriminate between sterile inflammation and bacterial infection.ConclusionsThe results of this study suggest that the detection of sterile infections with Tc-99m-ibu is possible and highly encouraging.en_US
dc.description.sponsorshipEge University Scientific Research Project (Bornova-Izmir, Turkey) [11NBE010]en_US
dc.description.sponsorshipPresent study was partially financially supported by the Ege University Scientific Research Project numbered 11NBE010 (Bornova-Izmir, Turkey).en_US
dc.identifier.doi10.1080/03639045.2023.2235009
dc.identifier.endpage484en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762
dc.identifier.issue8en_US
dc.identifier.pmid37458266en_US
dc.identifier.scopus2-s2.0-85165409170en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1080/03639045.2023.2235009
dc.identifier.urihttps://hdl.handle.net/11454/100550
dc.identifier.volume49en_US
dc.identifier.wosWOS:001032257100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofDrug Development and Industrial Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240825_Gen_US
dc.subjectIbuprofenen_US
dc.subjecttechnetium-99men_US
dc.subjectin vivo biodistributionen_US
dc.subjectinfectionen_US
dc.subjectinflammationen_US
dc.subjectNSAIDen_US
dc.subject>en_US
dc.subjectBiological Distributionen_US
dc.subjectRadioiodinationen_US
dc.subjectOlmesartanen_US
dc.subjectTraceren_US
dc.titleIn vivo behavior of technetium-99m labeled ibuprofen in infection and inflamation animal modelsen_US
dc.typeArticleen_US

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