Altered hippocampal formation shape in first-episode depressed patients at 5-year follow-up

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dc.contributor.authorIsikli, Serhan
dc.contributor.authorUgurlu, Onur
dc.contributor.authorDurmusoglu, Ece
dc.contributor.authorKizilates, Gozde
dc.contributor.authorKitis, Omer
dc.contributor.authorOzan, Erol
dc.contributor.authorEker, Cagdas
dc.contributor.authorCoburn, Kerry
dc.contributor.authorGonul, Ali Saffet
dc.date.accessioned2019-10-27T21:55:20Z
dc.date.available2019-10-27T21:55:20Z
dc.date.issued2013
dc.departmentEge Üniversitesien_US
dc.description.abstractIt is generally accepted that patients with major depressive disorder have smaller hippocampus size compared to healthy people. However, it is still not known if this situation exists before the onset of the disease or is a result of the toxic mechanism created by the depression itself. The findings of the long-term follow-up studies of first-episode depressed patients might contribute to solve the ongoing problem. In this study, the hippocampus of 18 first-episode patients who were followed-up for 5 years, were compared with those of healthy controls. There were no volumetric differences among groups neither at the baseline nor after 5 years of follow-up. However, shape analyses, using high dimensional mapping methods, revealed regional structural changes in the head and tail of the hippocampal formation in CA1 and subiculum regions in patients at the follow-up. Furthermore, a significant negative correlation was found with the number of days in depression without antidepressant treatment in the CA1 region in the head and tail of the hippocampal formation bilaterally. The findings of this study support the hypothesis that pathophysiological processes of depression induce structural alterations in depressed patients. (C) 2012 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipEge University Research FundEge University; Ihsan Dogramaci Foundationen_US
dc.description.sponsorshipThis study was supported by the research grants from Ege University Research Fund and Ihsan Dogramaci Foundation.en_US
dc.identifier.doi10.1016/j.jpsychires.2012.08.022en_US
dc.identifier.endpage55en_US
dc.identifier.issn0022-3956
dc.identifier.issn1879-1379
dc.identifier.issue1en_US
dc.identifier.pmid23069650en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpsychires.2012.08.022
dc.identifier.urihttps://hdl.handle.net/11454/48213
dc.identifier.volume47en_US
dc.identifier.wosWOS:000312354400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofJournal of Psychiatric Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor depressive disorderen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectHippocampusen_US
dc.subjectFollow-upen_US
dc.titleAltered hippocampal formation shape in first-episode depressed patients at 5-year follow-upen_US
dc.typeArticleen_US

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