Effects of Functional Pinealectomy on Immunity, Hematopoietic, Gastrointestinal and Urinary Systems in Experimentally Malnutritioned Rats

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dc.authoridCevik, Ozge/0000-0002-9325-3757
dc.authoriduyanikgil, Yigit/0000-0002-4016-0522
dc.contributor.authorTurgut, Yaar Bari
dc.contributor.authorSahin, Cem
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorYilmaz, Mustafa
dc.contributor.authorTomruk, Canberk
dc.contributor.authorGencer, Cevat
dc.contributor.authorCevik, Ozge
dc.date.accessioned2024-08-31T07:46:40Z
dc.date.available2024-08-31T07:46:40Z
dc.date.issued2024
dc.departmentEge Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to demonstrate morphological changes in immunity, hematopoietic, gastrointestinal and urinary systems in different melatonin (MEL) release situations in a rat model of protein energy malnutrition (PEM). Method: A total of 32 adult male Wistar rats were assigned into four equal groups: normal control; PEM light/dark; PEM light, called functional pinealectomy (Px); and PEM dark. PEM was produced with a 50% restricted diet, Px was produced by keeping rats in continuous light environment for 24 hours, and complete blood count and serum albumin level were analyzed at the end of the 6-week experimental period. Measurements of weights of body and some visceral organs were obtained, biochemical and morphological parameters were analyzed in addition to measurements of malondialdehyde (MDA), total glutatione (GSH), tumor necrosis factor (TNF)-alpha and interleukin-10 (IL-10) in tissue samples. Results: A reduction in the weights of body and visceral organs of animals in the PEM groups was accompanied by hypoalbuminemia, anemia, leukopenia and lymphopenia, and higher MDA, GSH, TNF-alpha and IL-10 levels in visceral tissues. There was a significant decrease in parenchymal cells of the liver and spleen, duodenal villi, lymphoid structures and kidney glomeruli, but there was an increase in the spleen capsule thickness and renal Bowman's space, sinusoidal congestion and fat accumulation in the liver. Importantly, these findings were milder in the PEM dark group, while they were prominent in the PEM light group. Conclusion: This study suggests that MEL has a protective role in reducing the negative effects of PEM, making it a potential therapeutic agent for further investigation.en_US
dc.description.sponsorshipFunding: The authors received no financial support for the research, authorship, and/or publication of this article.en_US
dc.identifier.doi10.33808/clinexphealthsci.1259883
dc.identifier.endpage333en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage324en_US
dc.identifier.trdizinid1250841en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.1259883
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1250841
dc.identifier.urihttps://hdl.handle.net/11454/104163
dc.identifier.volume14en_US
dc.identifier.wosWOS:001285132200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical and Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240831_Uen_US
dc.subjectFunctional Pinealectomyen_US
dc.subjectMalnutritionen_US
dc.subjectMelatoninen_US
dc.subjectProtein Energy Malnutritionen_US
dc.subjectRaten_US
dc.titleEffects of Functional Pinealectomy on Immunity, Hematopoietic, Gastrointestinal and Urinary Systems in Experimentally Malnutritioned Ratsen_US
dc.typeArticleen_US

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