The benefit of salt restriction in the treatment of end-stage renal disease by haemodialysis

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dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorTumuklu, Murat
dc.contributor.authorOzkahya, Mehmet
dc.contributor.authorOzdogan, Oner
dc.contributor.authorAsci, Gulay
dc.contributor.authorDuman, Soner
dc.contributor.authorToz, Huseyin
dc.contributor.authorCan, Levent H.
dc.contributor.authorBasci, Ali
dc.contributor.authorOk, Ercan
dc.date.accessioned2019-10-27T20:19:15Z
dc.date.available2019-10-27T20:19:15Z
dc.date.issued2009
dc.departmentEge Üniversitesien_US
dc.description.abstractBackground. Most haemodialysis (HD) centres use anti-hypertensive drugs for the management of hypertension, whereas some centres apply dietary salt restriction strategy. In this retrospective cross-sectional study, we assessed the effectiveness and cardiac consequences of these two strategies. Methods. We enrolled all patients from two dialysis centres, who had been on a standard HD programme at the same centre for at least 1 year. All patients underwent echocardiographic evaluation. Clinical data were obtained from patients' charts. Centre A (n = 190) practiced 'salt restriction' strategy and Centre B (n = 204) practiced anti-hypertensive-based strategy. Salt restriction was defined as managing high blood pressure (BP) via lowering dry weight by strict salt restriction and insistent ultrafiltration without using anti-hypertensive drugs. Results. There was no difference regarding age, gender, diabetes, history of cardiovascular disease and efficiency of dialysis between centres. Antihypertensive drugs were used in 7% of the patients in Centre A and 42% in Centre B (P < 0.01); interdialytic weight gain was significantly lower in Centre A (2.29 +/- 0.83 kgversus 3.31 +/- 1.12 kg, P < 0.001). Mean systolic and diastolic blood pressures were similar in the two centres. However, Centre A had lower left ventricular (LV) mass (indexed for height(2.7): 59 +/- 16 versus 74 +/- 27 g/m(2.7), P < 0.0001). The frequency of LV hypertrophy was lower in Centre A (74% versus 88%, P < 0.001). Diastolic and systolic functions were better preserved in Centre A. Intradialytic hypotension (hypotensive episodes/100 patient sessions) was more frequent in Centre B (11 versus 27, P < 0.01). Conclusions. This cross-sectional study suggests that salt restriction and reduced prescription of antihypertensive drugs may limit LV hypertrophy, better preserve LV functions and reduce intradialytic hypotension in HD patients.en_US
dc.identifier.doi10.1093/ndt/gfn599en_US
dc.identifier.endpage962en_US
dc.identifier.issn0931-0509
dc.identifier.issue3en_US
dc.identifier.pmid19004849en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage956en_US
dc.identifier.urihttps://doi.org/10.1093/ndt/gfn599
dc.identifier.urihttps://hdl.handle.net/11454/41374
dc.identifier.volume24en_US
dc.identifier.wosWOS:000263605000041en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofNephrology Dialysis Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectechocardiographyen_US
dc.subjecthaemodialysisen_US
dc.subjecthypertensionen_US
dc.subjectleft ventricular hypertrophyen_US
dc.subjectsalt restrictionen_US
dc.titleThe benefit of salt restriction in the treatment of end-stage renal disease by haemodialysisen_US
dc.typeArticleen_US

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